Abstract

The molecular study of anti-receptor antibody induced internalization of the p185 receptor will be undertaken. During the course of the studies we will define the effects of homodimeric (pl85-pl85) and heterodimeric receptors (pl85-EGFr). The influence of ligands on internalization processes will be compared to anti-receptor antibodies in vivo on transformed cells in a novel therapeutic model.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA055306-02
Application #
3199815
Study Section
Immunobiology Study Section (IMB)
Project Start
1992-05-01
Project End
1995-04-30
Budget Start
1993-05-01
Budget End
1994-04-30
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Cai, Zheng; Fu, Ting; Nagai, Yasuhiro et al. (2013) scFv-based ""Grababody"" as a general strategy to improve recruitment of immune effector cells to antibody-targeted tumors. Cancer Res 73:2619-27
Du, Taofeng; Nagai, Yasuhiro; Xiao, Yan et al. (2013) Lysosome-dependent p300/FOXP3 degradation and limits Treg cell functions and enhances targeted therapy against cancers. Exp Mol Pathol 95:38-45
Huang, J-M; Nagatomo, I; Suzuki, E et al. (2013) YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14. Oncogene 32:2220-9
Runkle, E Aaron; Zhang, Hongtao; Cai, Zheng et al. (2012) Reversion of the ErbB malignant phenotype and the DNA damage response. Exp Mol Pathol 93:324-33
Lam, Lian; McAndrew, Nicholas; Yee, Marla et al. (2012) Challenges in the clinical utility of the serum test for HER2 ECD. Biochim Biophys Acta 1826:199-208
Berezov, A; Cai, Z; Freudenberg, J A et al. (2012) Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin. Oncogene 31:1938-48
Song, Xiaomin; Li, Bin; Xiao, Yan et al. (2012) Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell Rep 1:665-75
Fu, Weihua; Madan, Elena; Yee, Marla et al. (2012) Progress of molecular targeted therapies for prostate cancers. Biochim Biophys Acta 1825:140-52
Ponde, Datta E; Su, ZiFen; Berezov, Alan et al. (2011) Development of anti-EGF receptor peptidomimetics (AERP) as tumor imaging agent. Bioorg Med Chem Lett 21:2550-3
Cai, Zheng; Zhang, Hongtao; Liu, Jing et al. (2010) Targeting erbB receptors. Semin Cell Dev Biol 21:961-6

Showing the most recent 10 out of 12 publications