Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA055414-08A1
Application #
2843973
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Program Officer
Forry, Suzanne L
Project Start
1991-07-05
Project End
2003-06-30
Budget Start
2000-07-26
Budget End
2001-06-30
Support Year
8
Fiscal Year
2000
Total Cost
$233,577
Indirect Cost
Name
Kansas City University of Medicine/Biosciences
Department
Family Medicine
Type
Schools of Osteopathy
DUNS #
City
Kansas City
State
MO
Country
United States
Zip Code
64106
Hartman, William R; Walters, D Eric; Hentosh, Patricia (2007) Presence of the anti-leukemic nucleotide analog, 2-chloro-2'-deoxyadenosine-5'-monophosphate, in a promoter sequence alters DNA binding of TATA-binding protein (TBP). Arch Biochem Biophys 459:223-32
Hartman, William R; Hentosh, Patricia (2004) The antileukemia drug 2-chloro-2'-deoxyadenosine: an intrinsic transcriptional antagonist. Mol Pharmacol 65:227-34
Foley, Theodore T; Hentosh, Patricia; Walters, D Eric (2004) 2-Chloro-2'-deoxyadenosine: alteration of DNA:TATA element binding protein (TBP) interactions. J Mol Model 10:32-7
Lawrenzi, James; Bunnell, Amy; Hentosh, Patricia (2003) Nucleotide excision repair-deficient human cells in culture exhibit decreased survival after 2-chlorodeoxyadenosine treatment. Anticancer Res 23:3141-5
Yuh, S H; Tibudan, M; Hentosh, P (1998) Analysis of 2-chloro-2'-deoxyadenosine incorporation into cellular DNA by quantitative polymerase chain reaction. Anal Biochem 262:1-8
Hentosh, P; Tibudan, M (1997) 2-Chloro-2'-deoxyadenosine, an antileukemic drug, has an early effect on cellular mitochondrial function. Mol Pharmacol 51:613-9
Hentosh, P; Tibudan, M; Grippo, P (1995) A human factor that recognizes DNA substituted with 2-chloroadenine, an antileukemic purine analog. Mol Carcinog 13:245-53
Hentosh, P; Tibudan, M (1995) In vitro transcription of DNA containing 2-chloro-2'-deoxyadenosine monophosphate. Mol Pharmacol 48:897-904
Hentosh, P; Grippo, P (1994) Template 2-chloro-2'-deoxyadenosine monophosphate inhibits in vitro DNA synthesis. Mol Pharmacol 45:955-61
Hentosh, P; Grippo, P (1994) 2-Chloro-2'-deoxyadenosine monophosphate residues in DNA enhance susceptibility to 3'-->5' exonucleases. Biochem J 302 ( Pt 2):567-71

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