Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA055735-05
Application #
2096851
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1992-02-01
Project End
1997-06-30
Budget Start
1996-02-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Fiore, Emilio; Fusco, Carlo; Romero, Pedro et al. (2002) Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity. Oncogene 21:5213-23
Yu, Wei-Hsuan; Woessner Jr, J Frederick; McNeish, John D et al. (2002) CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling. Genes Dev 16:307-23
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Stamenkovic, I (2000) Matrix metalloproteinases in tumor invasion and metastasis. Semin Cancer Biol 10:415-33
Peterson, R M; Yu, Q; Stamenkovic, I et al. (2000) Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites. Am J Pathol 156:2159-67
Biancone, L; Cantaluppi, V; Boccellino, M et al. (1999) Activation of CD40 favors the growth and vascularization of Kaposi's sarcoma. J Immunol 163:6201-8
Biancone, L; Stamenkovic, I; Cantaluppi, V et al. (1999) Expression of L-selectin ligands by transformed endothelial cells enhances T cell-mediated rejection. J Immunol 162:5263-9
Yu, Q; Stamenkovic, I (1999) Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev 13:35-48
Skelton, T P; Zeng, C; Nocks, A et al. (1998) Glycosylation provides both stimulatory and inhibitory effects on cell surface and soluble CD44 binding to hyaluronan. J Cell Biol 140:431-46
Zeng, C; Toole, B P; Kinney, S D et al. (1998) Inhibition of tumor growth in vivo by hyaluronan oligomers. Int J Cancer 77:396-401

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