We propose to conduct the first large case-control interview study of risk factors for childhood neuroblastoma. About 640 cases (under age 19 years at diagnosis) will be identified through the Childrens Cancer Study Group (CCSG) and the Pediatric Oncology Group (POG). Parents of cases and of 640 controls matched on age, sex, and race will be interviewed by telephone. Controls will be selected by random digit telephone dialing. The study will evaluate the relative importance of risk factors for neuroblastoma which were reported from previous studies. These include: maternal use of medications during pregnancy (specifically alcohol, diuretics and a group of drugs that includes amphetamines, antidepressants, antipsychotics and tranquilizers); parental employment in the electronics industry and occupational exposures to electromagnetic fields; maternal age at birth and subjects length of gestation and birth weight. The study will also evaluate drugs used by the mother during pregnancy for their potential to cause transplacental exposure of the fetus to N-nitroso compounds. Information on other potential risk factors such as family medical, gestational and delivery history will also be collected. It will examine the possibility of neuroblastoma having a similar set of risk factors in common with other childhood cancers. Since most of the patients have data collected on clinical, biologic and genetic markers, we will analyze the potential environmental risk factors separately for subgroups of patients defined by such characteristics as disease stage and N-myc oncogene amplification. This study can provide important new insights into the etiology of childhood cancer since neuroblastoma's pattern of occurrence in very early childhood suggests that parental or in utero exposures may play an important role in its etiology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA057004-04
Application #
2097749
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1991-09-30
Project End
1996-07-31
Budget Start
1994-09-01
Budget End
1995-07-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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Bluhm, Elizabeth C; Daniels, Julie; Pollock, Brad H et al. (2006) Maternal use of recreational drugs and neuroblastoma in offspring: a report from the Children's Oncology Group (United States). Cancer Causes Control 17:663-9
McCall, Erin E; Olshan, Andrew F; Daniels, Julie L (2005) Maternal hair dye use and risk of neuroblastoma in offspring. Cancer Causes Control 16:743-8
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Cook, Michael N; Olshan, Andrew F; Guess, Harry A et al. (2004) Maternal medication use and neuroblastoma in offspring. Am J Epidemiol 159:721-31
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De Roos, A J; Teschke, K; Savitz, D A et al. (2001) Parental occupational exposures to electromagnetic fields and radiation and the incidence of neuroblastoma in offspring. Epidemiology 12:508-17

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