We propose a 5-year continuation of the largest follow-up study of African-American women, the Black Women's Health Study (BWHS). We have followed 59,000 U.S. black women biennially since 1995, collected information on medical, reproductive, lifestyle, psychosocial, and socioeconomic factors, identified incident disease and deaths, and collected cheek cell samples from 26,800 participants. The overarching goal is to elucidate risk factors for cancers with disproportionately high incidence or mortality rates in black women, prominent among which are breast and colorectal cancer, and to elucidate causes of important nonmalignant conditions. Continued follow-up will increase the number of incident breast cancer cases to ~2,400, colorectal cancers to ~500, all-cause deaths to ~3,500, and cancer deaths to ~1,500. Compared with white women, black women have higher breast cancer mortality rates, colorectal cancer incidence and mortality rates, and all- cause and cancer mortality rates. Black women also experience more racism, tend to live in neighborhoods of lower socioeconomic status, have less access to healthy foods, and are more likely to have experienced poverty as children and as adults.
Aims of this proposal address aspects of these exposures and outcomes that are of special relevance to black women.
Novel aims i nclude the assessment of the relation of experiences of racism to all-cause and cancer mortality;poor diet quality, including restaurant food consumption ("fast food"), to breast and colorectal cancer incidence and all-cause and cancer mortality;and life-course socioeconomic status to obesity and all-cause and cancer mortality. This proposal also addresses the genetic etiology of breast cancer. Under separate funding, we are assessing two genes, FGFR2 and TNRC9 (which have been associated with breast cancer risk in genome wide association studies of European-ancestry women) to identify SNPs associated with breast cancer risk in the BWHS. Here we propose a novel aim based on those findings, to assess effect modification -- by physical activity, obesity, and reproductive factors -- of associations found in the BWHS in order to identify groups of black women at high risk of breast cancer. Thus, the proposed continuation of the BWHS will provide crucial information for the effort to reduce black/white health disparities.

Public Health Relevance

U.S. black women develop more aggressive breast cancer tumor types and have disproportionately high breast cancer mortality rates, colorectal cancer incidence and mortality rates, and cancer death rates relative to white women. The proposed study will extend data collection in the Black Women's Health Study, the largest follow-up study of U.S. black women, to obtain sufficient cases to assess a range of novel hypotheses concerning behavioral, psychosocial, and socioeconomic factors that may contribute to these differences. Better understanding of the causes of the increased risks among U.S. black women should lead to more effective preventive measures and reductions in health disparities.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058420-20
Application #
8472332
Study Section
Epidemiology of Cancer Study Section (EPIC)
Program Officer
Martin, Damali
Project Start
1994-09-02
Project End
2014-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
20
Fiscal Year
2013
Total Cost
$1
Indirect Cost
Name
Boston University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Yao, Song; Haddad, Stephen A; Hu, Qiang et al. (2016) Genetic variations in vitamin D-related pathways and breast cancer risk in African American women in the AMBER consortium. Int J Cancer 138:2118-26
Shields, Alexandra E; Wise, Lauren A; Ruiz-Narvaez, Edward A et al. (2016) Childhood abuse, promoter methylation of leukocyte NR3C1 and the potential modifying effect of emotional support. Epigenomics 8:1507-1517
Coogan, Patricia F; White, Laura F; Yu, Jeffrey et al. (2016) Long term exposure to NO2 and diabetes incidence in the Black Women's Health Study. Environ Res 148:360-6
Ruiz-Narváez, Edward A; Sucheston-Campbell, Lara; Bensen, Jeannette T et al. (2016) Admixture Mapping of African-American Women in the AMBER Consortium Identifies New Loci for Breast Cancer and Estrogen-Receptor Subtypes. Front Genet 7:170
Bethea, Traci N; Rosenberg, Lynn; Castro-Webb, Nelsy et al. (2016) Family History of Cancer in Relation to Breast Cancer Subtypes in African American Women. Cancer Epidemiol Biomarkers Prev 25:366-73
Campbell, Peter T; Newton, Christina C; Freedman, Neal D et al. (2016) Body Mass Index, Waist Circumference, Diabetes, and Risk of Liver Cancer for U.S. Adults. Cancer Res 76:6076-6083
Ruiz-Narváez, Edward A; Haddad, Stephen A; Rosenberg, Lynn et al. (2016) Birth weight modifies the association between central nervous system gene variation and adult body mass index. J Hum Genet 61:193-8
Ruiz-Narváez, Edward A; Haddad, Stephen A; Lunetta, Kathryn L et al. (2016) Gene-based analysis of the fibroblast growth factor receptor signaling pathway in relation to breast cancer in African American women: the AMBER consortium. Breast Cancer Res Treat 155:355-63
Bethea, Traci N; Palmer, Julie R; Rosenberg, Lynn et al. (2016) Neighborhood Socioeconomic Status in Relation to All-Cause, Cancer, and Cardiovascular Mortality in the Black Women's Health Study. Ethn Dis 26:157-64
Palmer, Julie R; Gerlovin, Hanna; Bethea, Traci N et al. (2016) Predicted 25-hydroxyvitamin D in relation to incidence of breast cancer in a large cohort of African American women. Breast Cancer Res 18:86

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