Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058538-03
Application #
2099225
Study Section
Virology Study Section (VR)
Project Start
1993-09-30
Project End
1997-08-31
Budget Start
1995-09-26
Budget End
1997-08-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Saint Louis University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103
Toth, Karoly; Doronin, Konstantin; Kuppuswamy, Mohan et al. (2005) Adenovirus immunoregulatory E3 proteins prolong transplants of human cells in immunocompetent mice. Virus Res 108:149-59
Toth, Karoly; Spencer, Jacqueline F; Tollefson, Ann E et al. (2005) Cotton rat tumor model for the evaluation of oncolytic adenoviruses. Hum Gene Ther 16:139-46
Lichtenstein, Drew L; Doronin, Konstantin; Toth, Karoly et al. (2004) Adenovirus E3-6.7K protein is required in conjunction with the E3-RID protein complex for the internalization and degradation of TRAIL receptor 2. J Virol 78:12297-307
Ying, Baoling; Wold, William S M (2003) Adenovirus ADP protein (E3-11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B. Virology 313:224-34
Tollefson, Ann E; Scaria, Abraham; Ying, Baoling et al. (2003) Mutations within the ADP (E3-11.6K) protein alter processing and localization of ADP and the kinetics of cell lysis of adenovirus-infected cells. J Virol 77:7764-78
Zanardi, Tom A; Yei, Soonpin; Lichtenstein, Drew L et al. (2003) Distinct domains in the adenovirus E3 RIDalpha protein are required for degradation of Fas and the epidermal growth factor receptor. J Virol 77:11685-96
Doronin, Konstantin; Toth, Karoly; Kuppuswamy, Mohan et al. (2003) Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus. Virology 305:378-87
Tarakanova, Vera L; Wold, William S M (2003) Transforming growth factor beta1 receptor II is downregulated by E1A in adenovirus-infected cells. J Virol 77:9324-36
Toth, Karoly; Tarakanova, Vera; Doronin, Konstantin et al. (2003) Radiation increases the activity of oncolytic adenovirus cancer gene therapy vectors that overexpress the ADP (E3-11.6K) protein. Cancer Gene Ther 10:193-200
Lichtenstein, Drew L; Krajcsi, Peter; Esteban, David J et al. (2002) Adenovirus RIDbeta subunit contains a tyrosine residue that is critical for RID-mediated receptor internalization and inhibition of Fas- and TRAIL-induced apoptosis. J Virol 76:11329-42

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