Abstract

The objective of this proposal is to investigate the hormonal requirements for the development of ovarian and testicular tumors in inhibin-deficient mice and the cachexia that is associated with the progression of these tumors. Using the inhibin-deficient mouse model developed by the investigator, the following studies are proposed.
Aim 1 will examine the individual roles of FSH and LH in tumor development and progression in inhibin-deficient mice.
Aim 2 will characterize the requirements for gonadal steroids in the development and progression of tumors in the inhibin-deficient mice.
Aim 3 will determine if overexpression of follistatin can prevent the activin-mediated cachexia-like syndrome that occurs in the inhibin-deficient mice.
Aim 4 will define the pattern of expression/extinction of cell cycle regulatory molecules that accompanies tumor development and growth.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA060651-06
Application #
2683541
Study Section
Biochemical Endocrinology Study Section (BCE)
Program Officer
Marks, Cheryl L
Project Start
1993-08-01
Project End
2001-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Pathology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Balhara, Jyoti; Shan, Lianyu; Zhang, Jingbo et al. (2017) Pentraxin 3 deletion aggravates allergic inflammation through a TH17-dominant phenotype and enhanced CD4 T-cell survival. J Allergy Clin Immunol 139:950-963.e9
Matzuk, Martin M; Burns, Kathleen H (2012) Genetics of mammalian reproduction: modeling the end of the germline. Annu Rev Physiol 74:503-28
Roy, Angshumoy; Matzuk, Martin M (2011) Reproductive tract function and dysfunction in women. Nat Rev Endocrinol 7:517-25
Hawkins, Shannon M; Buchold, Gregory M; Matzuk, Martin M (2011) Minireview: The roles of small RNA pathways in reproductive medicine. Mol Endocrinol 25:1257-79
Creighton, Chad J; Benham, Ashley L; Zhu, Huifeng et al. (2010) Discovery of novel microRNAs in female reproductive tract using next generation sequencing. PLoS One 5:e9637
Nagaraja, Ankur K; Middlebrook, Brooke S; Rajanahally, Saneal et al. (2010) Defective gonadotropin-dependent ovarian folliculogenesis and granulosa cell gene expression in inhibin-deficient mice. Endocrinology 151:4994-5006
Nalam, Roopa L; Matzuk, Martin M (2010) Local signalling environments and human male infertility: what we can learn from mouse models. Expert Rev Mol Med 12:e15
Hawkins, S M; Matzuk, M M (2010) Oocyte-somatic cell communication and microRNA function in the ovary. Ann Endocrinol (Paris) 71:144-8
Creighton, Chad J; Fountain, Michael D; Yu, Zhifeng et al. (2010) Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers. Cancer Res 70:1906-15
Yatsenko, A N; Iwamori, N; Iwamori, T et al. (2010) The power of mouse genetics to study spermatogenesis. J Androl 31:34-44

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