Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA064186-02
Application #
2106500
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1995-07-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Chin, Joanna Y; Glazer, Peter M (2009) Repair of DNA lesions associated with triplex-forming oligonucleotides. Mol Carcinog 48:389-99
Lonkar, Pallavi; Kim, Ki-Hyun; Kuan, Jean Y et al. (2009) Targeted correction of a thalassemia-associated beta-globin mutation induced by pseudo-complementary peptide nucleic acids. Nucleic Acids Res 37:3635-44
Schleifman, Erica B; Chin, Joanna Y; Glazer, Peter M (2008) Triplex-mediated gene modification. Methods Mol Biol 435:175-90
Chin, Joanna Y; Kuan, Jean Y; Lonkar, Pallavi S et al. (2008) Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids. Proc Natl Acad Sci U S A 105:13514-9
Kim, Ki-Hyun; Nielsen, Peter E; Glazer, Peter M (2007) Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids. Nucleic Acids Res 35:7604-13
Chin, Joanna Y; Schleifman, Erica B; Glazer, Peter M (2007) Repair and recombination induced by triple helix DNA. Front Biosci 12:4288-97
Knauert, Melissa P; Kalish, Jennifer M; Hegan, Denise C et al. (2006) Triplex-stimulated intermolecular recombination at a single-copy genomic target. Mol Ther 14:392-400
Knauert, Melissa P; Lloyd, Janice A; Rogers, Faye A et al. (2005) Distance and affinity dependence of triplex-induced recombination. Biochemistry 44:3856-64
Kalish, Jennifer M; Seidman, Michael M; Weeks, Daniel L et al. (2005) Triplex-induced recombination and repair in the pyrimidine motif. Nucleic Acids Res 33:3492-502
Rogers, Faye A; Manoharan, Muthiah; Rabinovitch, Peter et al. (2004) Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotides. Nucleic Acids Res 32:6595-604

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