Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA064983-03
Application #
2107747
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1994-02-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1998-01-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Fox Chase Cancer Center
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Lee, Brian D; French, Kevin J; Zhuang, Yan et al. (2003) Development of a syngeneic in vivo tumor model and its use in evaluating a novel P-glycoprotein modulator, PGP-4008. Oncol Res 14:49-60
Lawrence, D S; Copper, J E; Smith, C D (2001) Structure-activity studies of substituted quinoxalinones as multiple-drug-resistance antagonists. J Med Chem 44:594-601
Xia, Z; Smith, C D (2001) Total synthesis of dendroamide A, a novel cyclic peptide that reverses multiple drug resistance. J Org Chem 66:3459-66
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Dinh, T Q; Smith, C D; Du, X et al. (1998) Design, synthesis, and evaluation of the multidrug resistance-reversing activity of D-glucose mimetics of hapalosin. J Med Chem 41:981-7
Zhang, X; Smith, C D (1996) Microtubule effects of welwistatin, a cyanobacterial indolinone that circumvents multiple drug resistance. Mol Pharmacol 49:288-94
Ogino, J; Moore, R E; Patterson, G M et al. (1996) Dendroamides, new cyclic hexapeptides from a blue-green alga. Multidrug-resistance reversing activity of dendroamide A. J Nat Prod 59:581-6
Smith, C D; Zilfou, J T; Stratmann, K et al. (1995) Welwitindolinone analogues that reverse P-glycoprotein-mediated multiple drug resistance. Mol Pharmacol 47:241-7
Zilfou, J T; Smith, C D (1995) Differential interactions of cytochalasins with P-glycoprotein. Oncol Res 7:435-43
Smith, C D; Prinsep, M R; Caplan, F R et al. (1994) Reversal of multiple drug resistance by tolyporphin, a novel cyanobacterial natural product. Oncol Res 6:211-8