Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA065942-02
Application #
2109135
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1995-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
City
Buffalo
State
NY
Country
United States
Zip Code
14263
Alhonen, L; Pietila, M; Halmekyto, M et al. (1999) Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine. Mol Pharmacol 55:693-8
Suppola, S; Pietila, M; Parkkinen, J J et al. (1999) Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue. Biochem J 338 ( Pt 2):311-6
Alhonen, L; Karppinen, A; Uusi-Oukari, M et al. (1998) Correlation of polyamine and growth responses to N1,N11-diethylnorspermine in primary fetal fibroblasts derived from transgenic mice overexpressing spermidine/spermine N1-acetyltransferase. J Biol Chem 273:1964-9
Fogel-Petrovic, M; Kramer, D L; Vujcic, S et al. (1997) Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol Pharmacol 52:69-74
Pietila, M; Alhonen, L; Halmekyto, M et al. (1997) Activation of polyamine catabolism profoundly alters tissue polyamine pools and affects hair growth and female fertility in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase. J Biol Chem 272:18746-51
Fogel-Petrovic, M; Vujcic, S; Haner, R et al. (1996) Sequence specific antisense oligonucleotide analog interference with spermidine/spermine N1-acetyltransferase gene expression. Anticancer Res 16:2517-23
Fogel-Petrovic, M; Vujcic, S; Miller, J et al. (1996) Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines. FEBS Lett 391:89-94