Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA070018-02
Application #
2113974
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1995-07-18
Project End
1998-04-30
Budget Start
1996-06-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Arokium, Hubert; Kamata, Masakazu; Chen, Irvin (2009) Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cells. J Virol 83:11283-97
Kamata, Masakazu; Susanto, Melisa T; Chen, Irvin S Y (2009) Enhanced transthyretin tetramer stability following expression of an amyloid disease transsuppressor variant in mammalian cells. J Gene Med 11:103-11
Kamata, Masakazu; Watanabe, Nobumoto; Nagaoka, Yoshiko et al. (2008) Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2. J Virol 82:5672-82
Poon, Betty; Chang, Michael A; Chen, Irvin S Y (2007) Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA. J Virol 81:10515-23
Kamata, Masakazu; Wu, Raymond P; An, Dong Sung et al. (2006) Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death. Biochem Biophys Res Commun 348:1101-6
Poon, Betty; Chen, Irvin S Y (2003) Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA. J Virol 77:3962-72
Yuan, Huidong; Xie, Yi-Ming; Chen, Irvin S Y (2003) Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis. J Virol 77:2063-70
Gaynor, E M; Chen, I S (2001) Analysis of apoptosis induced by HIV-1 Vpr and examination of the possible role of the hHR23A protein. Exp Cell Res 267:243-57
Stewart, S A; Poon, B; Song, J Y et al. (2000) Human immunodeficiency virus type 1 vpr induces apoptosis through caspase activation. J Virol 74:3105-11
Jowett, J B; Xie, Y M; Chen, I S (1999) The presence of human immunodeficiency virus type 1 Vpr correlates with a decrease in the frequency of mutations in a plasmid shuttle vector. J Virol 73:7132-7

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