The general goal of this proposal is to develop non-intrusive optical spectroscopy as a real-time diagnostic technique for cervical dysplasia. In our previous study we have demonstrated good sensitivity and specificity of our fiber-optic probe for diagnosing HSIL in vivo and provided insight into the physical mechanisms which are the basis of our light scattering technique. In this work, we will build on our previous results, by modifying the fiber-optic probe and spectroscopy system to obtain better accuracy, developing a probe for the endocervical canal, studying the false positives and false negatives to understand the causes of inaccuracies, improving our understanding of the physical mechanisms that are the basis for the technique, and finally testing our diagnostic spectroscopic system in the clinic.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA071898-14
Application #
8307964
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Ossandon, Miguel
Project Start
1997-05-15
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
14
Fiscal Year
2012
Total Cost
$697,307
Indirect Cost
$275,167
Name
Los Alamos National Lab
Department
Type
DUNS #
175252894
City
Los Alamos
State
NM
Country
United States
Zip Code
87545
Nguyen, Jennifer; Hayakawa, Carole K; Mourant, Judith R et al. (2016) Development of perturbation Monte Carlo methods for polarized light transport in a discrete particle scattering model. Biomed Opt Express 7:2051-66
Mourant, Judith R; Marina, Oana C; Hebert, Tiffany M et al. (2014) Hemoglobin parameters from diffuse reflectance data. J Biomed Opt 19:37004
Sanders, Claire K; Mourant, Judith R (2013) Advantages of full spectrum flow cytometry. J Biomed Opt 18:037004
Nguyen, Jennifer; Hayakawa, Carole K; Mourant, Judith R et al. (2013) Perturbation Monte Carlo methods for tissue structure alterations. Biomed Opt Express 4:1946-63
Marina, Oana C; Sanders, Claire K; Mourant, Judith R (2012) Effects of acetic acid on light scattering from cells. J Biomed Opt 17:085002-1
Marina, Oana C; Sanders, Claire K; Mourant, Judith R (2012) Correlating light scattering with internal cellular structures. Biomed Opt Express 3:296-312
Mourant, Judith R; Bocklage, Therese J; Powers, Tamara M et al. (2009) Detection of cervical intraepithelial neoplasias and cancers in cervical tissue by in vivo light scattering. J Low Genit Tract Dis 13:216-223
Mourant, Judith R; Powers, Tamara M; Bocklage, Therese J et al. (2009) In vivo light scattering for the detection of cancerous and precancerous lesions of the cervix. Appl Opt 48:D26-35
Mourant, Judith R; Bocklage, Therese J; Powers, Tamara M et al. (2007) In vivo light scattering measurements for detection of precancerous conditions of the cervix. Gynecol Oncol 105:439-45
Jiang, Yi; Pjesivac-Grbovic, Jelena; Cantrell, Charles et al. (2005) A multiscale model for avascular tumor growth. Biophys J 89:3884-94

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