Both malignant melanoma and nevi (moles) arise from melanocytes, and in many cases, nevi are thought to be intermediate in the pathway from melanocyte to melanoma. The presence of nevi is the strongest predictor of melanoma risk, and individuals who have higher numbers of nevi have an estimated 6 to 7-fold increased risk of developing malignant melanoma. Most nevi are developed in childhood and an understanding of the genetic, environmental, and behavioral factors that contribute to nevus development and growth is essential for understanding the pathways to melanoma. This study began in 1998 with a sun protection intervention study of newborns, in which sun exposure and sun protection data were collected beginning at birth and nevus exams were conducted starting at age 3. In 2004, additional children were added to the cohort, for which sun exposure, sun protection, and skin exam data were collected annually at ages 6-10. This study is now the longest running annual longitudinal study of childhood nevus development in the world. The overall aim of this project is to continue studying this cohort (n=936) with nevus counts and interviews for five additional years, from 2010 - 2014, and to add two new data collection components: a genetic component and more detailed data collection on changes in growth and shape of individual nevi. Previous research indicates that the 12 - 16 age range covered by the 2010 - 2014 funding period will be the most critical period for emergent nevi during the lifespan. This study will examine increases in number of nevi, and changes in individual nevi, and how these are influenced by the interaction of genes, UV exposure, and sun protection behavior during this critical period. Up to 100 SNPs in genes already known to be associated with nevi or identified recently through genome wide studies (conducted by other researchers) as related to pigmentation, nevus development, or melanoma will be assessed. The comprehensive nature of the data collected through age 10, the data that will be collected during the course of the proposed study, and the availability of newly described genes that influence human pigmentation, nevus development and melanoma will allow for the most complete analysis of influences on nevus formation yet undertaken. The long-term clinical and public health significance of this research include: 1) a better understanding of the biological mechanisms that result in both nevus and melanoma development, which could lead to new treatments for melanoma;2) possible chemo-preventive agents to prevent nevus development and/or melanoma;and 3) more targeted public health recommendations regarding sun protective behaviors.

Public Health Relevance

Nevi (moles) are markers of melanoma risk, and in some cases are precursors of melanoma. This project will examine the genetic, environmental, and behavioral risk factors for nevus development in children. Understanding of these factors will lead to a better understanding of melanoma, and may suggest approaches for melanoma prevention or treatment.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA074592-12
Application #
8434260
Study Section
Epidemiology of Cancer Study Section (EPIC)
Program Officer
Perna, Frank
Project Start
1997-09-15
Project End
2015-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
12
Fiscal Year
2013
Total Cost
$494,226
Indirect Cost
$160,217
Name
University of Colorado Denver
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
BarĂ³n, Anna E; Asdigian, Nancy L; Gonzalez, Victoria et al. (2014) Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes. Cancer Epidemiol Biomarkers Prev 23:2829-39
Aalborg, Jenny; Morelli, Joseph G; Byers, Tim E et al. (2010) Effect of hair color and sun sensitivity on nevus counts in white children in Colorado. J Am Acad Dermatol 63:430-9
Sivamani, Raja K; Crane, Lori A; Dellavalle, Robert P (2009) The benefits and risks of ultraviolet tanning and its alternatives: the role of prudent sun exposure. Dermatol Clin 27:149-54, vi
Juhl, Ashley L; Byers, Tim E; Robinson, William A et al. (2009) The anatomic distribution of melanoma and relationships with childhood nevus distribution in Colorado. Melanoma Res 19:252-9
Aalborg, Jenny; Morelli, Joseph G; Mokrohisky, Stefan T et al. (2009) Tanning and increased nevus development in very-light-skinned children without red hair. Arch Dermatol 145:989-96
Pettijohn, Kelly J; Asdigian, Nancy L; Aalborg, Jenny et al. (2009) Vacations to waterside locations result in nevus development in Colorado children. Cancer Epidemiol Biomarkers Prev 18:454-63
Crane, Lori A; Mokrohisky, Stefan T; Dellavalle, Robert P et al. (2009) Melanocytic nevus development in Colorado children born in 1998: a longitudinal study. Arch Dermatol 145:148-56
Dodd, Athena T; Morelli, Joseph; Mokrohisky, Stefan T et al. (2007) Melanocytic nevi and sun exposure in a cohort of colorado children: anatomic distribution and site-specific sunburn. Cancer Epidemiol Biomarkers Prev 16:2136-43
Crane, Lori A; Deas, Ann; Mokrohisky, Stefan T et al. (2006) A randomized intervention study of sun protection promotion in well-child care. Prev Med 42:162-70
Dellavalle, Robert P; Johnson, Kathryn R; Hester, Eric J et al. (2005) Children with red hair have more freckles but fewer melanocytic nevi: results from a cohort study of 280 three-year-olds. Arch Dermatol 141:1042-3

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