Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA079837-01
Application #
2733441
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Program Officer
Forry, Suzanne L
Project Start
1999-02-01
Project End
2002-01-31
Budget Start
1999-02-01
Budget End
2000-01-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Wayne State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Beck, Frances W J; Eilender, Davi S; Dandashi, Mahmoud H et al. (2004) Factors affecting bryostatin 1-enhanced 2-CdA cytotoxicity in resistant B-cell chronic lymphocytic leukemia. Int J Mol Med 14:113-9
Mohammad, Ramzi M; Aboukameel, Amro; Nabha, Sanaa et al. (2002) Rituximab, Cyclophosphamide, Dexamethasone (RCD) regimen induces cure in WSU-WM xenograft model and a partial remission in previously treated Waldenstrom's macroglobulinemia patient. J Drug Target 10:405-10
Nabha, Sanaa M; Mohammad, Ramzi M; Dandashi, Mahmoud H et al. (2002) Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage. Clin Cancer Res 8:2735-41
Wall, N R; Beck, F W; Al-Katib, A M et al. (2001) Treatment-induced expression of anti-apoptotic proteins in WSU-CLL, a human chronic lymphocytic leukemia cell line. J Drug Target 9:329-39
Nabha, S M; Mohammad, R M; Wall, N R et al. (2001) Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: preclinical efficacy. Anticancer Drugs 12:57-63
Mohammad, R M; Wall, N R; Dutcher, J A et al. (2000) The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model. Clin Cancer Res 6:4950-6
Ahmad, I; Al-Katib, A M; Beck, F W et al. (2000) Sequential treatment of a resistant chronic lymphocytic leukemia patient with bryostatin 1 followed by 2-chlorodeoxyadenosine: case report. Clin Cancer Res 6:1328-32
Varterasian, M L; Mohammad, R M; Shurafa, M S et al. (2000) Phase II trial of bryostatin 1 in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Clin Cancer Res 6:825-8
Nabha, S M; Wall, N R; Mohammad, R M et al. (2000) Effects of combretastatin A-4 prodrug against a panel of malignant human B-lymphoid cell lines. Anticancer Drugs 11:385-92
Beck, F W; Al-Katib, A M; Ahmad, I et al. (2000) Bryostatin 1-induced modulation of nucleoside transporters and 2-chlorodeoxyadenosine influx in WSU-CLL cells. Int J Mol Med 5:341-7

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