Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA082768-03
Application #
6377421
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Moshell, Alan N
Project Start
1999-07-01
Project End
2002-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
3
Fiscal Year
2001
Total Cost
$180,229
Indirect Cost
Name
Pennsylvania State University
Department
Physiology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Nowotarski, Shannon L; Feith, David J; Shantz, Lisa M (2015) Skin Carcinogenesis Studies Using Mouse Models with Altered Polyamines. Cancer Growth Metastasis 8:17-27
Shi, Chenxu; Cooper, Timothy K; McCloskey, Diane E et al. (2012) S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion. Carcinogenesis 33:1310-8
Origanti, Sofia; Nowotarski, Shannon L; Carr, Theresa D et al. (2012) Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells. Biochem J 442:199-207
Nowotarski, Shannon L; Origanti, Sofia; Shantz, Lisa M (2011) Posttranscriptional regulation of ornithine decarboxylase. Methods Mol Biol 720:279-92
Nowotarski, Shannon L; Shantz, Lisa M (2010) Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model. J Biol Chem 285:31885-94
Levin, Victor A; Jochec, Jacob L; Shantz, Lisa M et al. (2007) Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy. Int J Cancer 121:2279-83
Feith, David J; Shantz, Lisa M; Shoop, Paula L et al. (2007) Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds. Mol Carcinog 46:453-65
Origanti, Sofia; Shantz, Lisa M (2007) Ras transformation of RIE-1 cells activates cap-independent translation of ornithine decarboxylase: regulation by the Raf/MEK/ERK and phosphatidylinositol 3-kinase pathways. Cancer Res 67:4834-42
Feith, David J; Origanti, Sofia; Shoop, Paula L et al. (2006) Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis. Carcinogenesis 27:1090-8
Kim, Sonia W; Mangold, Ursula; Waghorne, Carol et al. (2006) Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism. J Cell Sci 119:2583-91

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