Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA087006-03
Application #
6514619
Study Section
Pathobiochemistry Study Section (PBC)
Program Officer
Mietz, Judy
Project Start
2000-07-01
Project End
2005-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
3
Fiscal Year
2002
Total Cost
$279,180
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Long, Olivia S; Gosai, Sager J; Kwak, Joon Hyeok et al. (2011) Using Caenorhabditis elegans to study serpinopathies. Methods Enzymol 499:259-81
Luke, Cliff J; Pak, Stephen C; Askew, Yuko S et al. (2007) An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Cell 130:1108-19
Askew, David J; Cataltepe, Sule; Kumar, Vasantha et al. (2007) SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. J Biol Chem 282:24948-60
Luke, Cliff J; Pak, Stephen C; Askew, David J et al. (2006) Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species. Front Biosci 11:581-94
Pak, Stephen C; Tsu, Christopher; Luke, Cliff J et al. (2006) The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases. Biochemistry 45:4474-80
Jayakumar, Arumugam; Cataltepe, Sule; Kang, Ya'an et al. (2004) Production of serpins using baculovirus expression systems. Methods 32:177-84
Pak, Stephen C; Kumar, Vasantha; Tsu, Christopher et al. (2004) SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. J Biol Chem 279:15448-59
Cole, Elisabeth B; Miller, David; Rometo, David et al. (2004) Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin. Biochemistry 43:11750-9
Askew, David J; Askew, Yuko S; Kato, Yukari et al. (2004) Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus. Genomics 84:176-84
Askew, David J; Askew, Yuko S; Kato, Yukari et al. (2004) The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases. Genomics 84:166-75

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