Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA088738-07
Application #
6633862
Study Section
Biophysical Chemistry Study Section (BBCB)
Program Officer
Lees, Robert G
Project Start
1995-07-01
Project End
2004-05-31
Budget Start
2003-03-01
Budget End
2004-05-31
Support Year
7
Fiscal Year
2003
Total Cost
$275,231
Indirect Cost
Name
Harvard University
Department
Pathology
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Kumar, Kapil; Brady, Michael; Shapiro, Robert (2004) Selective abolition of pancreatic RNase binding to its inhibitor protein. Proc Natl Acad Sci U S A 101:53-8
Holloway, Daniel E; Chavali, Gayatri B; Hares, Michelle C et al. (2004) Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41. Biochemistry 43:1230-41
Kumar, Kapil; Jenkins, Jeremy L; Jardine, Anwar M et al. (2003) Inhibition of mammalian ribonucleases by endogenous adenosine dinucleotides. Biochem Biophys Res Commun 300:81-6
Jenkins, Jeremy L; Shapiro, Robert (2003) Identification of small-molecule inhibitors of human angiogenin and characterization of their binding interactions guided by computational docking. Biochemistry 42:6674-87
Tonan, Kenji; Xu, Ping; Jenkins, Jeremy L et al. (2003) Unexpected binding mode for 2'-phosphoadenosine-based nucleotide inhibitors in complex with human angiogenin revealed by heteronuclear NMR spectroscopy. Biochemistry 42:11137-49
Teufel, Daniel P; Kao, Richard Y T; Acharya, K Ravi et al. (2003) Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2). Biochemistry 42:1451-9
Jenkins, Jeremy L; Kao, Richard Y T; Shapiro, Robert (2003) Virtual screening to enrich hit lists from high-throughput screening: a case study on small-molecule inhibitors of angiogenin. Proteins 50:81-93
Holloway, Daniel E; Shapiro, Robert; Hares, Michelle C et al. (2002) Guest-host crosstalk in an angiogenin-RNase A chimeric protein. Biochemistry 41:10482-9
Leonidas, Demetres D; Shapiro, Robert; Subbarao, Gowtham V et al. (2002) Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency. Biochemistry 41:2552-62