X-ray mammography is the current clinical tool used for breast cancer detection. However, mammography is ionizing radiation and has unacceptable false negative rate for patients with radiodense breast tissues. These patients represent the general population of premenopausal women as well as those with fibrocystic tissue disease. Yet, cancer in younger women tends to be more virulent and grow faster. Consequently, there is a critical need to seek alternatives that could overcome the problems associated with x-ray mammography and that could become an excellent adjunct or competitive tool to conventional x-ray mammography. Non-ionizing, noninvasive near-infrared optical imaging has great potential to become such promising alternative for breast cancer detection. Based on the very recent development in this regard, we have identified an optical imaging method that combines both modern optical techniques and powerful computations. Our pilot clinical studies have shown that breast tumors can be detected using optical imaging, which indicates the possibility of clinical application of this technique for breast imaging and breast lesion detection characterization.
Our specific aims i n this project include (I) continued development of both two- and three-dimensional computer algorithms needed for generating images, (2) construction and test of an improved optical imaging system using three-dimensional tomographic data collection, (3) evaluation and optimization of this system using tissue phantom experiments, and (4) test of this optical imaging system in human subjects. We believe that the success of this research will provide solid evidence that simple steady-state, continuous-wave optical methods coupled with model-based image formation from tomographically measured data offers an imaging methodology with clinical relevance to the breast cancer detection.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA090533-05
Application #
6908140
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Nordstrom, Robert J
Project Start
2002-05-06
Project End
2008-04-30
Budget Start
2006-05-01
Budget End
2008-04-30
Support Year
5
Fiscal Year
2006
Total Cost
$257,121
Indirect Cost
Name
University of Florida
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
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Li, Changqing; Grobmyer, Stephen R; Massol, Nicole et al. (2008) Noninvasive in vivo tomographic optical imaging of cellular morphology in the breast: possible convergence of microscopic pathology and macroscopic radiology. Med Phys 35:2493-501
Yuan, Zhen; Wang, Qiang; Jiang, Huabei (2007) Reconstruction of optical absorption coefficient maps of heterogeneous media by photoacoustic tomography coupled with diffusion equation based regularized Newton method. Opt Express 15:18076-81
Li, Changqing; Grobmyer, Stephen R; Chen, Lin et al. (2007) Multispectral diffuse optical tomography with absorption and scattering spectral constraints. Appl Opt 46:8229-36
Yin, Lu; Wang, Qiang; Zhang, Qizhi et al. (2007) Tomographic imaging of absolute optical absorption coefficient in turbid media using combined photoacoustic and diffusing light measurements. Opt Lett 32:2556-8
Liang, Xiaoping; Zhang, Qizhi; Jiang, Huabei (2006) Quantitative reconstruction of refractive index distribution and imaging of glucose concentration by using diffusing light. Appl Opt 45:8360-5
Li, Changqing; Zhao, Hongzhi; Anderson, Bonnie et al. (2006) Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system. Med Phys 33:627-36
Li, Changqing; Jiang, Huabei (2005) Measurement of particle-size distribution and concentration in heterogeneous turbid media with multispectral diffuse optical tomography. Appl Opt 44:1838-44
Bartlett, Matthew; Huang, George; Larcom, Lyndon et al. (2004) Measurement of particle size distribution in mammalian cells in vitro by use of polarized light spectroscopy. Appl Opt 43:1296-307
Gu, Xuejun; Zhang, Qizhi; Bartlett, Matthew et al. (2004) Differentiation of cysts from solid tumors in the breast with diffuse optical tomography. Acad Radiol 11:53-60

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