The second five-year renewal of the Southern Community Cohort Study (SCCS) is proposed in this grant application. Progress during the initial nine years of the study has been exceptional. We achieved a final cohort size of approximately 86,000 adults aged 40-79, two-thirds of whom are African American, with detailed baseline data assembled for all and biological specimens in frozen storage for nearly 90%. The cohort is now under follow-up for cancer mortality and incidence and other health outcomes. Historically, large-scale recruitment of African Americans, a group disproportionately burdened by cancer, into health research studies has been challenging. However, we uniquely overcame many known barriers to inclusion by developing partnerships with a network of southern Community Health Centers (CHCs), institutions that provide basic health services primarily to America's poor and uninsured. The SCCS thus differs from all other cohort studies in racial composition and socioeconomic disadvantage, and tracks a population possibly at higher cancer risk than any American population segment studied to date.
Our specific aims for the renewal are (1) to continue passive follow-up of the cohort via linkages with various national and state registries to identify deaths, incident cancers and other health outcomes, (2) to continue active follow-up of the cohort via re-contact with participants to directly update exposure and health information, and (3) to conduct multiple new cohort and nested case-control analyses utilizing the baseline and follow-up data and stored DNA and blood specimens for evaluation of lifestyle, genetic and other risk or protective factors affecting the incidence of and disparities in the major cancers (lung, breast, prostate, and colon/rectum). We will evaluate hypotheses that the SCCS is uniquely or especially well positioned to address, many for the first time among African Americans, including the roles of obesity, vitamin D, specific infections (Chlamydia pneumoniae, Trichomonas vaginalis, Helicobacter pylori, and xenotropic murine leukemia virus-related virus), several nutrition-related pathways (one carbon metabolism, n-6 and n-3 polyunsaturated fatty acids and other dietary factors), cigarette mentholation, and use of the commonly prescribed glycemic control medication metformin, in relation to cancer risk and cancer disparities.

Public Health Relevance

African Americans experience a disproportionate burden of cancer for reasons that are only partly understood, but most existing US cohort studies include only small numbers of African Americans, impeding ability to investigate cancer risk determinants among blacks and factors that might underlie cancer disparities. The Southern Community Cohort Study (SCCS), whose second renewal is proposed in this grant application, has completed enrollment, baseline data collection, and the development of a rich biospecimen repository, and is now poised to provide crucial information to fill these knowledge gaps. With continuation of both participant follow-up and the testing of innovative scientific hypotheses, the SCCS will enhance the collective scientific knowledge base and have a sustained and powerful impact aimed at the amelioration of health disparities.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA092447-12
Application #
8517442
Study Section
Special Emphasis Panel (ZRG1-PSE-B (03))
Program Officer
Martin, Damali
Project Start
2001-09-30
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
12
Fiscal Year
2013
Total Cost
$3,702,887
Indirect Cost
$589,391
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Wang, Hansong; Burnett, Terrilea; Kono, Suminori et al. (2014) Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Nat Commun 5:4613
Signorello, Lisa B; Cohen, Sarah S; Williams, David R et al. (2014) Socioeconomic status, race, and mortality: a prospective cohort study. Am J Public Health 104:e98-e107
Milne, Roger L; Burwinkel, Barbara; Michailidou, Kyriaki et al. (2014) Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium. Hum Mol Genet 23:6096-111
Ng, Maggie C Y; Shriner, Daniel; Chen, Brian H et al. (2014) Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet 10:e1004517
Matthews, Charles E; Cohen, Sarah S; Fowke, Jay H et al. (2014) Physical activity, sedentary behavior, and cause-specific mortality in black and white adults in the Southern Community Cohort Study. Am J Epidemiol 180:394-405
Epplein, Meira; Burk, Raymond F; Cai, Qiuyin et al. (2014) A prospective study of plasma Selenoprotein P and lung cancer risk among low-income adults. Cancer Epidemiol Biomarkers Prev 23:1238-44
Sanderson, Maureen; Lipworth, Loren; Han, Xijing et al. (2014) Mammography use among women with and without diabetes: results from the Southern Community Cohort Study. J Epidemiol Glob Health 4:223-30
Hargreaves, Margaret K; Liu, Jianguo; Buchowski, Maciej S et al. (2014) Plasma selenium biomarkers in low income black and white americans from the southeastern United States. PLoS One 9:e84972
Sampson, Uchechukwu K A; Edwards, Todd L; Jahangir, Eiman et al. (2014) Factors associated with the prevalence of hypertension in the southeastern United States: insights from 69,211 blacks and whites in the Southern Community Cohort Study. Circ Cardiovasc Qual Outcomes 7:33-54
Bethea, Traci N; Kitahara, Cari M; Sonderman, Jennifer et al. (2014) A pooled analysis of body mass index and pancreatic cancer mortality in african americans. Cancer Epidemiol Biomarkers Prev 23:2119-25

Showing the most recent 10 out of 70 publications