Prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer deaths among American men. Prostate cancer etiology remains elusive but there is growing evidence that dietary patterns are associated with prostate carcinogenesis. The most consistent dietary finding is that diets high in fat or high-fat foods increase risk and there is increasing evidence that compounds found in vegetables (e.g., lycopene, glucosinolates) decrease risk. However, results are not consistent across studies and there is no scientific consensus for specific dietary recommendations to reduce prostate cancer risk. Non-dietary factors associated with risk include age, race and family history. These and other risk factors may interact with dietary components and alter the prooxidant-antioxidant balance in the prostate. This proposal is for a comprehensive investigation into the associations of dietary fat, fruit and vegetable intakes and polymorphisms in genes that encode oxidative stress regulatory enzymes with the risk of prostate cancer. Our hypothesis is that dietary and other factors that increase oxidative stress (e.g., dietary fat, smoking) are associated with increased risk of prostate cancer; dietary factors that decrease oxidative stress are associated with decreased risk of prostate cancer; and the magnitude of these risks will vary by cancer susceptibility genetic profile. We will test whether polymorphisms in genes whose products affect tissue responses to oxidative stress influence prostate cancer risk, and whether there are interactions of these polymorphisms with dietary factors related to oxidative stress. Our study sample is the 12,025 male participants in CARET (The Beta-Carotene and Retinol Efficacy Trial). To date, there are 718 confirmed cases of primary prostatic carcinoma. This proposed study will provide important information about prostate cancer etiology and suggest new strategies for prevention and control.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA096789-02
Application #
6765186
Study Section
Special Emphasis Panel (ZRG1-SNEM-5 (02))
Program Officer
Hartmuller, Virginia W
Project Start
2003-06-23
Project End
2006-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
2
Fiscal Year
2004
Total Cost
$596,004
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Bonn, Stephanie E; Barnett, Matt J; Thornquist, Mark et al. (2018) Body mass index and prostate cancer risk in the Carotene and Retinol Efficacy Trial. Eur J Cancer Prev :
Key, Timothy J; Appleby, Paul N; Travis, Ruth C et al. (2015) Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies. Am J Clin Nutr 102:1142-57
Crowe, Francesca L; Appleby, Paul N; Travis, Ruth C et al. (2014) Circulating fatty acids and prostate cancer risk: individual participant meta-analysis of prospective studies. J Natl Cancer Inst 106:
Cheng, Ting-Yuan David; King, Irena B; Barnett, Matt J et al. (2013) Serum phospholipid fatty acids, genetic variation in myeloperoxidase, and prostate cancer risk in heavy smokers: a gene-nutrient interaction in the carotene and retinol efficacy trial. Am J Epidemiol 177:1106-17
Cheng, Ting-Yuan David; Barnett, Matt J; Kristal, Alan R et al. (2011) Genetic variation in myeloperoxidase modifies the association of serum ?-tocopherol with aggressive prostate cancer among current smokers. J Nutr 141:1731-7
Neuhouser, Marian L; Barnett, Matt J; Kristal, Alan R et al. (2009) Dietary supplement use and prostate cancer risk in the Carotene and Retinol Efficacy Trial. Cancer Epidemiol Biomarkers Prev 18:2202-6
Choi, Ji-Yeob; Neuhouser, Marian L; Barnett, Matt J et al. (2008) Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort. Carcinogenesis 29:964-70
Neuhouser, Marian L; Barnett, Matt J; Kristal, Alan R et al. (2007) (n-6) PUFA increase and dairy foods decrease prostate cancer risk in heavy smokers. J Nutr 137:1821-7
Choi, Ji-Yeob; Neuhouser, Marian L; Barnett, Matt et al. (2007) Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers. Cancer Epidemiol Biomarkers Prev 16:1115-20
Joseph, Michael A; Moysich, Kirsten B; Freudenheim, Jo L et al. (2004) Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk. Nutr Cancer 50:206-13