In spite of the wealth of experimental, clinical and epidemiological data that have helped identify important genetic components and pathways in colorectal cancer (CRC), CRC continues to be the second leading cause of cancer associated death, with close to 50,000 deaths predicted for the year 2008 in the US alone. Because CRC arises predominantly in benign precursors (mainly the adenomatous polyps), which are likely to sojourn for many years before they turn malignant, CRC can be prevented largely through screening and prompt intervention. The goal of this renewal is to further explore, via a biomathematical description of the natural history of CRC, how screening and interventions can be applied most effectively to reduce the mortality associated with CRC

Public Health Relevance

Relevance from a clinical and public health perspective, the overarching goal of this renewal is to further develop and validate biomathematical models of the natural history of colorectal cancer for quantitative cancer risk prediction. These models are also meant to help clinicians manage cancer surveillance and interventions in patients with screen-detected precursor lesions and pre-clinical cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA107028-06
Application #
8020941
Study Section
Epidemiology of Cancer Study Section (EPIC)
Program Officer
Stedman, Margaret R
Project Start
2004-02-01
Project End
2013-12-31
Budget Start
2011-01-01
Budget End
2011-12-31
Support Year
6
Fiscal Year
2011
Total Cost
$244,422
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Jeon, Jihyoun; Meza, Rafael; Hazelton, William D et al. (2015) Incremental benefits of screening colonoscopy over sigmoidoscopy in average-risk populations: a model-driven analysis. Cancer Causes Control 26:859-70
Luebeck, E Georg; Curtius, Kit; Jeon, Jihyoun et al. (2013) Impact of tumor progression on cancer incidence curves. Cancer Res 73:1086-96
Hazelton, William D; Goodman, Gary; Rom, William N et al. (2012) Longitudinal multistage model for lung cancer incidence, mortality, and CT detected indolent and aggressive cancers. Math Biosci 240:20-34
Kosoff, Rachelle E; Gardiner, Kristin L; Merlo, Lauren M F et al. (2012) Development and characterization of an organotypic model of Barrett's esophagus. J Cell Physiol 227:2654-9
Dewanji, Anup; Jeon, Jihyoun; Meza, Rafael et al. (2011) Number and size distribution of colorectal adenomas under the multistage clonal expansion model of cancer. PLoS Comput Biol 7:e1002213
Hazelton, William D; Luebeck, E Georg (2011) Biomarker-based early cancer detection: is it achievable? Sci Transl Med 3:109fs9
Meza, Rafael; Jeon, Jihyoun; Renehan, Andrew G et al. (2010) Colorectal cancer incidence trends in the United States and United kingdom: evidence of right- to left-sided biological gradients with implications for screening. Cancer Res 70:5419-29
Jean, Larry W; Suchorolski, Martin T; Jeon, Jihyoun et al. (2010) Multiscale estimation of cell kinetics. Comput Math Methods Med 11:239-54
Merlo, Lauren M F; Shah, Najaf A; Li, Xiaohong et al. (2010) A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma. Cancer Prev Res (Phila) 3:1388-97
Luebeck, E Georg; Moolgavkar, Suresh H; Liu, Amy Y et al. (2008) Does folic acid supplementation prevent or promote colorectal cancer? Results from model-based predictions. Cancer Epidemiol Biomarkers Prev 17:1360-7

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