In recent years there have been a number of advances in SPECT imaging including improvements in reconstruction and compensation methods, and imaging systems. However, much of this work has been targeted at improvement of diagnostic procedures. The collection of quantitative imaging information is a critical step in dosimetry and treatment planning for targeted radionuclide therapy (TRT). Errors in the quantitative imaging methods can result in reduced efficacy or increased incidence of adverse side effects. The most commonly used quantitation methodology for TRT dosimetry is conjugate-view planar imaging, a method pioneered more than 20 years ago. The goal of this project is to develop, optimize, and evaluate, practical and clinically implementable quantitative imaging methods for use in estimating in vivo the cumulated activity (i.e., the number of radioactive decays that occur in a region or organ integrated over time). The methods will be Dased on combinations of planar and one or more SPECT scans performed on a SPECT/CT system and processed using quantitative SPECT reconstruction and planar processing techniques. Specifically, SPECT reconstruction algorithms for ln-111 and 1-131 photon emissions that account for scatter, attenuation, partial volume effects, and collimator penetration and scatter will be developed. Planar imaging methods that incorporate lateral as well as AP imaging acquisition and organ overlap correction based on SPECT scans will be examined to improve organ and tumor delineation and radioactivity quantitation. Monte Carlo simulations, physical phantoms, and patient data will be used to optimize and validate the methodologies. A population of mathematical phantoms, based on the results of patient studies, will be developed and used to model various anatomies and pharmacokinetics. The imaging parameters and acquisition techniques will be evaluated in terms of their influence on the estimation of dosimetric parameters. Quantitative imaging is a critical input to dosimetry calculations that are essential to TRT treatment planning. The work described in this proposal will develop and validate methodologies for improving quantitation in a practical and clinically implementable manner. If successful, this project will allow the development of more accurate treatment plans with the potential for greater therapeutic effect and fewer adverse reactions. It will also provide valuable methodological improvements for clinical studies trying to understand TRT dose-response relationships.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA109234-05
Application #
7749957
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Deye, James
Project Start
2006-03-01
Project End
2011-08-31
Budget Start
2010-02-01
Budget End
2011-08-31
Support Year
5
Fiscal Year
2010
Total Cost
$456,856
Indirect Cost
Name
Johns Hopkins University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Vicente, Esther M; Lodge, Martin A; Rowe, Steven P et al. (2017) Simplifying volumes-of-interest (VOIs) definition in quantitative SPECT: Beyond manual definition of 3D whole-organ VOIs. Med Phys 44:1707-1717
Mena, Esther; Taghipour, Mehdi; Sheikhbahaei, Sara et al. (2017) Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma. Clin Nucl Med 42:e227-e234
Jha, Abhinav K; Frey, Eric (2017) No-gold-standard evaluation of image-acquisition methods using patient data. Proc SPIE Int Soc Opt Eng 10136:
Mena, Esther; Sheikhbahaei, Sara; Taghipour, Mehdi et al. (2017) 18F-FDG PET/CT Metabolic Tumor Volume and Intratumoral Heterogeneity in Pancreatic Adenocarcinomas: Impact of Dual-Time Point and Segmentation Methods. Clin Nucl Med 42:e16-e21
Zimmerman, Brian E; Grošev, Darko; Buvat, Irène et al. (2017) Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification: An IAEA phantom study. Z Med Phys 27:98-112
Jha, Abhinav K; Caffo, Brian; Frey, Eric C (2016) A no-gold-standard technique for objective assessment of quantitative nuclear-medicine imaging methods. Phys Med Biol 61:2780-800
Yue, Jianting; Mauxion, Thibault; Reyes, Diane K et al. (2016) Comparison of quantitative Y-90 SPECT and non-time-of-flight PET imaging in post-therapy radioembolization of liver cancer. Med Phys 43:5779
Jha, Abhinav K; Frey, Eric C (2015) Estimating ROI activity concentration with photon-processing and photon-counting SPECT imaging systems. Proc SPIE Int Soc Opt Eng 9412:94120R
Jha, Abhinav K; Song, Na; Caffo, Brian et al. (2015) Objective evaluation of reconstruction methods for quantitative SPECT imaging in the absence of ground truth. Proc SPIE Int Soc Opt Eng 9416:94161K
Anizan, N; Wang, H; Zhou, X C et al. (2015) Factors affecting the repeatability of gamma camera calibration for quantitative imaging applications using a sealed source. Phys Med Biol 60:1325-37

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