Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA114403-01A1
Application #
7039317
Study Section
Hepatobiliary Pathophysiology Study Section (HBPP)
Program Officer
Knowlton, John R
Project Start
2006-04-01
Project End
2011-02-28
Budget Start
2006-04-01
Budget End
2007-02-28
Support Year
1
Fiscal Year
2006
Total Cost
$214,768
Indirect Cost
Name
Seattle Institute for Biomedical/Clinical Research
Department
Type
DUNS #
928470061
City
Seattle
State
WA
Country
United States
Zip Code
98108
Jusakul, Apinya; Loilome, Watcharin; Namwat, Nisana et al. (2013) Anti-apoptotic phenotypes of cholestan-3*,5*,6*-triol-resistant human cholangiocytes: characteristics contributing to the genesis of cholangiocarcinoma. J Steroid Biochem Mol Biol 138:368-75
Kuver, Rahul (2012) Mechanisms of oxysterol-induced disease: insights from the biliary system. Clin Lipidol 7:537-548
Jusakul, Apinya; Loilome, Watcharin; Namwat, Nisana et al. (2012) Liver fluke-induced hepatic oxysterols stimulate DNA damage and apoptosis in cultured human cholangiocytes. Mutat Res 731:48-57
Jusakul, Apinya; Khuntikeo, Narong; Haigh, W Geoffrey et al. (2012) Identification of biliary bile acids in patients with benign biliary diseases, hepatocellular carcinoma and cholangiocarcinoma. Asian Pac J Cancer Prev 13 Suppl:77-82
Kuver, Rahul (2011) Effects of statins on cholestasis: good, bad or indifferent? J Gastroenterol Hepatol 26:1467-9
Van Rooyen, Derrick M; Larter, Claire Z; Haigh, W Geoffrey et al. (2011) Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis. Gastroenterology 141:1393-403, 1403.e1-5
Jusakul, Apinya; Yongvanit, Puangrat; Loilome, Watcharin et al. (2011) Mechanisms of oxysterol-induced carcinogenesis. Lipids Health Dis 10:44
Kuver, Rahul (2010) Bioactive sphingolipids in the biliary tract: relevance for cholesterol gallstone disease. J Gastroenterol Hepatol 25:1020-3
Haigh, W Geoffrey; Wong, Thomas; Lee, Sum P (2006) The production of oxysterols in bile by activated human leukocytes. Biochem Biophys Res Commun 343:467-9