Breast cancer survivors confront a number of post-treatment problems including fatigue, decreased physical function, fears of recurrence, and treatment-related sequelae. Persistent fatigue, the most common and distressing problem, appears to be related in part to overactivation of the inflammatory network. Higher levels of depressive symptoms can effectively prime the inflammatory response, promoting larger NF-kappa B and proinflammatory responses to stressors. Physical activity interventions that simultaneously enhance physical performance and reduce depressive symptoms can reduce fatigue-related symptoms, as well as inflammation. This project provides the opportunity to examine mechanistic connections among fatigue, stressors, depressive symptoms, and proinflammatory cytokines both cross-section ally and longitudinally in a randomized clinical trial, building on preliminary studies that have demonstrated anti-inflammatory changes associated with yoga. A total of 200 stage I, II, and Ilia breast cancer survivors will be recruited, ages 40 and older;the women will have completed cancer treatment within the past year (except for tarnoxifen/aromatase inhibitors), and will be at least two months post surgery or adjuvant therapy or radiation, whichever occurred last. All of the women will have received chemotherapy as part of their treatment. Using a block-randomized design, participants will be assigned to either a 1 2-week (twice-weekly) hatha yoga intervention or a delayed intervention arm that receives the yoga intervention after a 6-month observation period. Differences between the two arms will be assessed at 3 months (at the conclusion of the 12-week intervention), and at 6 months (3 months after the formal intervention), controlling for any baseline (pre-randomization) measures. NF-kappa B and proinflammatory cytokine responses to a laboratory stressor will be assessed at baseline and 3 months.
AIMS : (1) The primary aim is to determine if the yoga intervention will decrease inflammation, fatigue, and depressive symptoms relative to the wait-list controls. Additional aims are (2) to ascertain the extent to which the intervention modulates psychological, behavioral, and physical functioning;(3) to evaluate the relationship between depressive symptoms and the magnitude of the physiological responses elicited by a laboratory stressor, as well as the relationship of both to fatigue;and (4) to assess the extent to which the yoga intervention wiII decrease physiological stress responses.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
Project #
Application #
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Mc Donald, Paige A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Ohio State University
Schools of Medicine
United States
Zip Code
Derry, Heather M; Jaremka, Lisa M; Bennett, Jeanette M et al. (2015) Yoga and self-reported cognitive problems in breast cancer survivors: a randomized controlled trial. Psychooncology 24:958-66
Jaremka, Lisa M; Peng, Juan; Bornstein, Robert et al. (2014) Cognitive problems among breast cancer survivors: loneliness enhances risk. Psychooncology 23:1356-64
Kiecolt-Glaser, Janice K; Bennett, Jeanette M; Andridge, Rebecca et al. (2014) Yoga's impact on inflammation, mood, and fatigue in breast cancer survivors: a randomized controlled trial. J Clin Oncol 32:1040-9
Kiecolt-Glaser, Janice K; Glaser, Ronald; Christian, Lisa M (2014) Omega-3 fatty acids and stress-induced immune dysregulation: implications for wound healing. Mil Med 179:129-33
Fagundes, Christopher P; Jaremka, Lisa M; Glaser, Ronald et al. (2014) Attachment anxiety is related to Epstein-Barr virus latency. Brain Behav Immun 41:232-8
Fagundes, Christopher P; Jaremka, Lisa M; Malarkey, William B et al. (2014) Attachment style and respiratory sinus arrhythmia predict post-treatment quality of life in breast cancer survivors. Psychooncology 23:820-6
Lindgren, Monica E; Fagundes, Christopher P; Alfano, Catherine M et al. (2013) Beta-blockers may reduce intrusive thoughts in newly diagnosed cancer patients. Psychooncology 22:1889-94
Jaremka, Lisa M; Fagundes, Christopher P; Peng, Juan et al. (2013) Loneliness promotes inflammation during acute stress. Psychol Sci 24:1089-97
Jaremka, Lisa M; Fagundes, Christopher P; Glaser, Ronald et al. (2013) Loneliness predicts pain, depression, and fatigue: understanding the role of immune dysregulation. Psychoneuroendocrinology 38:1310-7
Fagundes, Christopher P; Glaser, Ronald; Malarkey, William B et al. (2013) Childhood adversity and herpesvirus latency in breast cancer survivors. Health Psychol 32:337-44

Showing the most recent 10 out of 28 publications