Breast cancer survivors confront a number of post-treatment problems including fatigue, decreased physical function, fears of recurrence, and treatment-related sequelae. Persistent fatigue, the most common and distressing problem, appears to be related in part to overactivation of the inflammatory network. Higher levels of depressive symptoms can effectively prime the inflammatory response, promoting larger NF-kappa B and proinflammatory responses to stressors. Physical activity interventions that simultaneously enhance physical performance and reduce depressive symptoms can reduce fatigue-related symptoms, as well as inflammation. This project provides the opportunity to examine mechanistic connections among fatigue, stressors, depressive symptoms, and proinflammatory cytokines both cross-section ally and longitudinally in a randomized clinical trial, building on preliminary studies that have demonstrated anti-inflammatory changes associated with yoga. A total of 200 stage I, II, and Ilia breast cancer survivors will be recruited, ages 40 and older;the women will have completed cancer treatment within the past year (except for tarnoxifen/aromatase inhibitors), and will be at least two months post surgery or adjuvant therapy or radiation, whichever occurred last. All of the women will have received chemotherapy as part of their treatment. Using a block-randomized design, participants will be assigned to either a 1 2-week (twice-weekly) hatha yoga intervention or a delayed intervention arm that receives the yoga intervention after a 6-month observation period. Differences between the two arms will be assessed at 3 months (at the conclusion of the 12-week intervention), and at 6 months (3 months after the formal intervention), controlling for any baseline (pre-randomization) measures. NF-kappa B and proinflammatory cytokine responses to a laboratory stressor will be assessed at baseline and 3 months.
AIMS : (1) The primary aim is to determine if the yoga intervention will decrease inflammation, fatigue, and depressive symptoms relative to the wait-list controls. Additional aims are (2) to ascertain the extent to which the intervention modulates psychological, behavioral, and physical functioning;(3) to evaluate the relationship between depressive symptoms and the magnitude of the physiological responses elicited by a laboratory stressor, as well as the relationship of both to fatigue;and (4) to assess the extent to which the yoga intervention wiII decrease physiological stress responses.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA126857-06
Application #
8255356
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Mc Donald, Paige A
Project Start
2007-06-01
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2014-04-30
Support Year
6
Fiscal Year
2012
Total Cost
$322,603
Indirect Cost
$111,060
Name
Ohio State University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Derry, Heather M; Jaremka, Lisa M; Bennett, Jeanette M et al. (2015) Yoga and self-reported cognitive problems in breast cancer survivors: a randomized controlled trial. Psychooncology 24:958-66
Kiecolt-Glaser, Janice K; Bennett, Jeanette M; Andridge, Rebecca et al. (2014) Yoga's impact on inflammation, mood, and fatigue in breast cancer survivors: a randomized controlled trial. J Clin Oncol 32:1040-9
Fagundes, Christopher P; Jaremka, Lisa M; Glaser, Ronald et al. (2014) Attachment anxiety is related to Epstein-Barr virus latency. Brain Behav Immun 41:232-8
Jaremka, Lisa M; Peng, Juan; Bornstein, Robert et al. (2014) Cognitive problems among breast cancer survivors: loneliness enhances risk. Psychooncology 23:1356-64
Kiecolt-Glaser, Janice K; Glaser, Ronald; Christian, Lisa M (2014) Omega-3 fatty acids and stress-induced immune dysregulation: implications for wound healing. Mil Med 179:129-33
Fagundes, Christopher P; Jaremka, Lisa M; Malarkey, William B et al. (2014) Attachment style and respiratory sinus arrhythmia predict post-treatment quality of life in breast cancer survivors. Psychooncology 23:820-6
Jaremka, Lisa M; Fagundes, Christopher P; Glaser, Ronald et al. (2013) Loneliness predicts pain, depression, and fatigue: understanding the role of immune dysregulation. Psychoneuroendocrinology 38:1310-7
Fagundes, Christopher P; Glaser, Ronald; Kiecolt-Glaser, Janice K (2013) Stressful early life experiences and immune dysregulation across the lifespan. Brain Behav Immun 27:8-12
Fagundes, Christopher P; Glaser, Ronald; Malarkey, William B et al. (2013) Childhood adversity and herpesvirus latency in breast cancer survivors. Health Psychol 32:337-44
Jaremka, Lisa M; Lindgren, Monica E; Kiecolt-Glaser, Janice K (2013) Synergistic relationships among stress, depression, and troubled relationships: insights from psychoneuroimmunology. Depress Anxiety 30:288-96

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