Abstract

Public Health Relevance

Lymphoma is an often fatal cancer. To improve the cure rate in this disease we need to know its biology. Our proposal to study the miR-155 gene in lymphomas will improve our grasp on the mechanisms for this tumor development and open avenues for the implementation of novel more effective and less toxic treatments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA138747-02
Application #
8035503
Study Section
Molecular Oncogenesis Study Section (MONC)
Program Officer
Howcroft, Thomas K
Project Start
2010-03-01
Project End
2014-12-31
Budget Start
2011-01-01
Budget End
2011-12-31
Support Year
2
Fiscal Year
2011
Total Cost
$298,894
Indirect Cost

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229

  Publications

Lin, An-Ping; Abbas, Saman; Kim, Sang-Woo et al. (2015) D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2. Nat Commun 6:7768
Jeong, D; Kim, J; Nam, J et al. (2015) MicroRNA-124 links p53 to the NF-?B pathway in B-cell lymphomas. Leukemia 29:1868-74
Bouamar, Hakim; Jiang, Daifeng; Wang, Long et al. (2015) MicroRNA 155 control of p53 activity is context dependent and mediated by Aicda and Socs1. Mol Cell Biol 35:1329-40
Ortega, M; Bhatnagar, H; Lin, A-P et al. (2015) A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies. Leukemia 29:968-76
Jiang, Daifeng; Aguiar, Ricardo C T (2014) MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-?1/SMAD5 signaling module. Blood 123:86-93
Bouamar, Hakim; Abbas, Saman; Lin, An-Ping et al. (2013) A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma. Blood 122:726-33
Toledo, Rodrigo A; Qin, Yuejuan; Srikantan, Subramanya et al. (2013) In vivo and in vitro oncogenic effects of HIF2A mutations in pheochromocytomas and paragangliomas. Endocr Relat Cancer 20:349-59
Kim, Sang-Woo; Ramasamy, Kumaraguruparan; Bouamar, Hakim et al. (2012) MicroRNAs miR-125a and miR-125b constitutively activate the NF-?B pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20). Proc Natl Acad Sci U S A 109:7865-70
Rai, Deepak; Kim, Sang-Woo; McKeller, Morgan R et al. (2010) Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc Natl Acad Sci U S A 107:3111-6
Jung, Inkyung; Aguiar, Ricardo C T (2009) MicroRNA-155 expression and outcome in diffuse large B-cell lymphoma. Br J Haematol 144:138-40

Showing the most recent 10 out of 11 publications