The long-term objective of this project is to improve devices and techniques for microwave tumor ablation and extend its application into new patient populations by optimizing system design and energy delivery in several tissue types. Microwave ablation is superior to currently available technologies in many respects: microwaves provide rapid volumetric heating, leading to more precise and complete treatments;microwave heating is less dependent on tissue properties, making it more suitable for emerging targets (e.g., lung and bone);and using multiple antennas improves treatment control, precision and efficacy. Unfortunately, current systems have failed to deliver on these promises and patients who could benefit from improved therapies have suffered. This proposal is based on the idea that understanding more about microwave tissue heating will facilitate development of optimized systems and techniques that will enhance patient benefit and expand the role of microwave ablation in cancer care. As microwave ablation systems begin to enter the marketplace, optimized treatment protocols will be required to enhance patient benefit and expand the role of microwave ablation in clinical cancer care. To this end, we propose to: 1) Create improved numerical models of tissue to more accurately predict device performance. Hypothesis: Accurate tissue models improve numerical simulations, easing design and treatment optimization. 2) Optimize antenna designs and power delivery for tissue-specific treatments Hypotheses: Antenna design and frequencies can be optimized for specific tissues or treatment targets. Applying high-power pulses will more rapidly coagulate tissue microvasculature to improve efficacy. When combined, these optimizations will create ablations 50% faster and 25% larger than current systems. 3) Develop multiple-antenna application techniques to optimize treatment speed and specificity. Hypotheses: Multiple-antenna techniques improve efficacy and precision, allowing more tailored treatments without increasing invasiveness. Ablations can be created by 50% faster and 40% larger than current systems. 4) Facilitate real-time adaptive power control by using integrated treatment monitoring Hypothesis: Treatment monitoring can be accomplished without imaging, using only the interstitial applicator. If successful, this project will advance knowledge of microwave tissue heating, and create innovative and unique approaches to power delivery that utilize all of the advantages that microwaves offer.
These aims will substantially change clinical practice by increasing the size of tumors that can be treated with microwaves, further broadening the scope of microwave ablation to areas outside the liver and increasing the number of patients benefiting from minimally invasive treatments.

Public Health Relevance

This proposal will combine the best of engineering and medicine to better understand how ablations are created, develop tools for improved system design, and create a cancer treatment platform that requires minimal invasiveness to provide maximal patient benefit.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA142737-04S1
Application #
8596258
Study Section
Radiation Therapeutics and Biology Study Section (RTB)
Program Officer
Ogunbiyi, Peter
Project Start
2010-02-01
Project End
2014-12-31
Budget Start
2013-01-01
Budget End
2014-12-31
Support Year
4
Fiscal Year
2013
Total Cost
$15,443
Indirect Cost
$4,341
Name
University of Wisconsin Madison
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Chiang, Jason; Birla, Sohan; Bedoya, Mariajose et al. (2015) Modeling and validation of microwave ablations with internal vaporization. IEEE Trans Biomed Eng 62:657-63
Lubner, Meghan G; Ziemlewicz, Tim J; Hinshaw, J Louis et al. (2014) Creation of short microwave ablation zones: in vivo characterization of single and paired modified triaxial antennas. J Vasc Interv Radiol 25:1633-40
Hinshaw, J Louis; Lubner, Meghan G; Ziemlewicz, Timothy J et al. (2014) Percutaneous tumor ablation tools: microwave, radiofrequency, or cryoablation--what should you use and why? Radiographics 34:1344-62
Chiang, Jason; Wang, Peng; Brace, Christopher L (2013) Computational modelling of microwave tumour ablations. Int J Hyperthermia 29:308-17
Andreano, Anita; Brace, Christopher L (2013) A comparison of direct heating during radiofrequency and microwave ablation in ex vivo liver. Cardiovasc Intervent Radiol 36:505-11
Chiang, Jason; Hynes, Kieran A; Bedoya, Mariajose et al. (2013) A dual-slot microwave antenna for more spherical ablation zones: ex vivo and in vivo validation. Radiology 268:382-9
Lubner, Meghan G; Hinshaw, J Louis; Andreano, Anita et al. (2012) High-powered microwave ablation with a small-gauge, gas-cooled antenna: initial ex vivo and in vivo results. J Vasc Interv Radiol 23:405-11
Knavel, Erica M; Hinshaw, J Louis; Lubner, Meghan G et al. (2012) High-powered gas-cooled microwave ablation: shaft cooling creates an effective stick function without altering the ablation zone. AJR Am J Roentgenol 198:W260-5
Wang, Peng; Brace, Christopher L (2012) Tissue dielectric measurement using an interstitial dipole antenna. IEEE Trans Biomed Eng 59:115-21
Sonntag, P David; Hinshaw, J Louis; Lubner, Meghan G et al. (2011) Thermal ablation of lung tumors. Surg Oncol Clin N Am 20:369-87, ix

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