Curative treatment of local and/or regional breast cancer requires surgery and adjuvant therapy such as thermotherapy. In thermal treatment of breast cancer, the tissue is exposed to high temperatures that damage and kill cancer cells with minimal injury to normal tissues. The overall goal of our research program is to develop an image-guided, molecular specific photothermal therapy of cancer using targeted metal nanoparticles. Specifically, using targeted plasmonic nanosensors and an advanced, in-vivo, noninvasive, functional, molecular specific imaging technology (i.e., integrated ultrasound, photoacoustic and elasticity imaging), photothermal therapy can be greatly improved. Indeed, before the therapeutic procedure, using ultrasound (anatomical and blood flow imaging) and elastography (biomechanical functional imaging), the tumor will be non-invasively imaged to develop an appropriate treatment plan. Furthermore, the delivery and interaction of molecular specific photoabsorbers with cancerous tissue will be imaged using photoacoustics - a technique capable of in-vivo imaging of plasmonic nanoparticles at sufficient depth. During the therapy, the real-time imaging system will be used to guide photothermal therapy by tracking the temperature rise and, therefore, monitoring cancer treatment. Finally, after the therapy, the combined imaging will be used to accurately assess the short-term and the long-term treatment outcome. The central theme of the current application is threefold: to develop multifunctional plasmonic nanoparticles acting as both photoabsorbers for photothermal therapy and contrast agent for molecular and thermal imaging;to design and build a laboratory prototype of the integrated ultrasound, photoacoustic and elasticity imaging system;and to initially test the developed nanoparticles and imaging technology in 3-D tissue phantoms and small animal cancer model ex vivo and in vivo. Therefore, all theoretical and experimental studies will be conducted to evaluate the applicability of the molecular specific, image-guided photothermal therapy to treat cancer. At the end of the study, we will outline the design and technical specifications of a clinical image- guided photothermal therapy system.
Cancer is a disease characterized by uncontrollable, abnormal growth of cells. The resulting tumor can invade and destroy the surrounding healthy tissue. Cancer is the second leading cause of death in the United States, exceeded only by heart disease. Breast cancer treatment often requires surgery and adjuvant therapy such as thermotherapy. In thermal treatment of breast cancer the tissue is exposed to high temperatures that damage and kill cancer cells with minimal injury to normal tissues. The primary goal of thermal treatment of cancer is to selectively heat a small volume of cancerous cells leading to tumor necrosis while protecting the surrounding healthy tissue. Thus, to successfully perform photothermal cancer therapy, an imaging technique that can help effectively plan, guide and monitor the photothermal therapy is needed. The overall goal of our research program is to develop the targeted multifunctional nanoparticles and the combined ultrasound, photoacoustic and elasticity imaging system to assist photothermal therapy. Before the therapeutic procedure, the tumor will be non-invasively imaged to develop an appropriate treatment plan. During the therapy, the real-time imaging system will be used to guide photothermal therapy by tracking the temperature rise and monitoring the cancer treatment. Finally, after the therapy, the combined imaging will be used to accurately assess the short-term and the long-term treatment outcome.
|Hannah, Alexander S; Luke, Geoffrey P; Emelianov, Stanislav Y (2016) Blinking Phase-Change Nanocapsules Enable Background-Free Ultrasound Imaging. Theranostics 6:1866-76|
|Gray, J P; Dana, N; Dextraze, K L et al. (2016) Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions. Ultrason Imaging 38:96-112|
|Mallidi, Srivalleesha; Kim, Seungsoo; Karpiouk, Andrei et al. (2015) Visualization of molecular composition and functionality of cancer cells using nanoparticle-augmented ultrasound-guided photoacoustics. Photoacoustics 3:26-34|
|Kim, Seungsoo; Chen, Yun-Sheng; Luke, Geoffrey P et al. (2014) In-vivo ultrasound and photoacoustic image- guided photothermal cancer therapy using silica-coated gold nanorods. IEEE Trans Ultrason Ferroelectr Freq Control 61:891-7|
|Qu, Min; Mehrmohammadi, Mohammad; Truby, Ryan et al. (2014) Contrast-enhanced magneto-photo-acoustic imaging in vivo using dual-contrast nanoparticles. Photoacoustics 2:55-62|
|Hannah, Alexander; Luke, Geoffrey; Wilson, Katheryne et al. (2014) Indocyanine green-loaded photoacoustic nanodroplets: dual contrast nanoconstructs for enhanced photoacoustic and ultrasound imaging. ACS Nano 8:250-9|
|Luke, Geoffrey P; Emelianov, Stanislav Y (2014) Optimization of in vivo spectroscopic photoacoustic imaging by smart optical wavelength selection. Opt Lett 39:2214-7|
|Mehrmohammadi, Mohammad; Yoon, Soon Joon; Yeager, Douglas et al. (2013) Photoacoustic Imaging for Cancer Detection and Staging. Curr Mol Imaging 2:89-105|
|Chen, Yun-Sheng; Frey, Wolfgang; Walker, Charles et al. (2013) Sensitivity enhanced nanothermal sensors for photoacoustic temperature mapping. J Biophotonics 6:534-42|
|Bayer, Carolyn L; Kelvekar, Juili; Emelianov, Stanislav Y (2013) Influence of nanosecond pulsed laser irradiance on the viability of nanoparticle-loaded cells: implications for safety of contrast-enhanced photoacoustic imaging. Nanotechnology 24:465101|
Showing the most recent 10 out of 26 publications