This proposal by a new investigator examines decisions made by advanced cancer patients regarding early phase clinical trials. Advances in basic and translational research may herald the arrival of new, targeted therapies that will improve cancer treatment and reduce mortality, but all of these therapies must be tested for safety in early phase (EP) clinical trials before they can benefit the public. Recruiting more patients to EP trials may speed the development of new cancer therapies, and some have argued that trials For aim 1, focus groups are used to describe providers In aim 2, an Advanced Cancer Cohort (ACC, n=150) is assembled using validated quantitative instruments, qualitative interviews, and clinic participant- observation to gather data on ACC patients'EP experiences and decisions as well as the perspectives of family caregivers and providers.
Aim 3 analyzes ACC patients

Public Health Relevance

Developing new cancer therapies is a national priority, but the advanced cancer patients in whom these therapies are first tested are highly vulnerable. This study examines how advanced cancer patients make decisions about participating in a trial of a new therapy. The study aims to gather information that can improve the system for developing cancer therapies without putting vulnerable cancer patients at undue risk.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA152195-05
Application #
8658026
Study Section
Special Emphasis Panel (ZRG1-HDM-B (90))
Program Officer
Nelson, Wendy
Project Start
2010-06-01
Project End
2015-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
5
Fiscal Year
2014
Total Cost
$431,819
Indirect Cost
$152,324
Name
University of California San Francisco
Department
Social Sciences
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Garrett, Sarah B; Koenig, Christopher J; Trupin, Laura et al. (2017) What advanced cancer patients with limited treatment options know about clinical research: a qualitative study. Support Care Cancer 25:3235-3242
Dohan, Daniel; Garrett, Sarah B; Rendle, Katharine A et al. (2016) The Importance Of Integrating Narrative Into Health Care Decision Making. Health Aff (Millwood) 35:720-5
Abramson, Corey M; Dohan, Daniel (2015) BEYOND TEXT: USING ARRAYS TO REPRESENT AND ANALYZE ETHNOGRAPHIC DATA. Sociol Methodol 45:272-319
Koenig, Christopher J; Ho, Evelyn Y; Trupin, Laura et al. (2015) An exploratory typology of provider responses that encourage and discourage conversation about complementary and integrative medicine during routine oncology visits. Patient Educ Couns 98:857-63