Image-guided treatment planning for pleural Photodynamic Therapy Abstract The overall objective of this grant is to develop an integrated system for real-time PDT dosimetry and light source monitoring during intracavitary photodynamic therapy. We propose to develop an infra- red camera-based system for real-time tracking of the motion of the light source used for treatment. The same tracking system will be used to digitize the surface contour of the cavity being treated for light fluence rate calculation. An optical fiber-based spectroscopic probe, coupled with the IR camera tracking device, will be used to determine absorption spectra at multiple points on the pleural cavity surface before and after PDT. Analysis of the absorption spectrum will determine the tissue oxygenation and the sensitizer concentration at these points. The same probe will be capable of performing fluorescence spectroscopy to verify drug concentration in-vivo before and after PDT. The absorption spectrum will also be used to determine the tissue optical properties in-vivo and use these points as input for light fluence rate calculation. To improve the spatial resolution of the heterogeneous tissue optical properties, we plan to develop a spectral reflectance imaging system to determine the surface distribution of optical properties in tissue before and after PDT. The temporal variations of light fluence rate, absorption spectrum, and fluorescence emission will be measured in- vivo at 7 selected points and compared with calculations using a light fluence calculation algorithm which takes into account the geometry and optical properties of the cavity. PDT dose will be calculated as a product of drug concentration and light fluence rate. We hypothesize that using PDT dose as a PDT dosimetry quantity to optimize light source movement will result in improvement of the spatial uniformity of PDT treatment and thus its efficacy. Further improvement of the PDT dose by a new dosimetric quantity, reacted singlet oxygen concentration that takes into account of light fluence rate effect, will be examined in a preclinical model.

Public Health Relevance

Relevance Statement: Pleural cancer is a serious public health problem for which there is no curative treatment available. Photodynamic therapy in combination with surgery offers a potential locally curative treatment, which has been demonstrated to substantially prolong patient's lives. The result of this project will substantially improve the light delivery homogeneity and quantification of PDT dose for pleural PDT, potentially resulting improved effectiveness of PDT as a curative therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA154562-01A1
Application #
8237404
Study Section
Radiation Therapeutics and Biology Study Section (RTB)
Program Officer
Wong, Rosemary S
Project Start
2012-03-09
Project End
2016-11-30
Budget Start
2012-03-09
Budget End
2012-11-30
Support Year
1
Fiscal Year
2012
Total Cost
$320,178
Indirect Cost
$112,678
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kim, Michele M; Darafsheh, Arash; Ahmad, Mahmoud et al. (2016) PDT Dose Dosimeter for Pleural Photodynamic Therapy. Proc SPIE Int Soc Opt Eng 9694:96940Y
Ong, Yi Hong; Zhu, Timothy C (2016) Analytic function for predicting light fluence rate of circular fields on a semi-infinite turbid medium. Opt Express 24:26261-26281
Penjweini, Rozhin; Kim, Michele M; Dimofte, Andrea et al. (2016) Deformable medical image registration of pleural cavity for photodynamic therapy by using finite-element based method. Proc SPIE Int Soc Opt Eng 9701:970106
Zhu, Timothy C; Lu, Amy; Ong, Yi-Hong (2016) An improved analytic function for predicting light fluence rate in circular fields on a semi-infinite geometry. Proc SPIE Int Soc Opt Eng 9706:97061D
Penjweini, Rozhin; Kim, Michele M; Liu, Baochang et al. (2016) Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling. J Biophotonics 9:1344-1354
Penjweini, Rozhin; Kim, Michele M; Finlay, Jarod C et al. (2016) Investigating the impact of oxygen concentration and blood flow variation on photodynamic therapy. Proc SPIE Int Soc Opt Eng 9694:
Gemmell, Nathan R; McCarthy, Aongus; Kim, Michele M et al. (2016) A compact fiber-optic probe-based singlet oxygen luminescence detection system. J Biophotonics :
Kim, Michele M; Penjweini, Rozhin; Liang, Xing et al. (2016) Explicit macroscopic singlet oxygen modeling for benzoporphyrin derivative monoacid ring A (BPD)-mediated photodynamic therapy. J Photochem Photobiol B 164:314-322
Qiu, Haixia; Kim, Michele M; Penjweini, Rozhin et al. (2016) Macroscopic singlet oxygen modeling for dosimetry of Photofrin-mediated photodynamic therapy: an in-vivo study. J Biomed Opt 21:88002
Qiu, Haixia; Kim, Michele M; Penjweini, Rozhin et al. (2016) Dosimetry study of PHOTOFRIN-mediated photodynamic therapy in a mouse tumor model. Proc SPIE Int Soc Opt Eng 9694:

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