We propose to characterize organ absorbed dose data for a large population of pediatric subjects who receive CT scans at our facility by matching real subjects with individuals in a large library of individuals of different age and body type developed from our existing realistic body models. We will manually segment images for 50 pediatric patients and calculate organs doses via Monte Carlo radiation transport calculations. Then we will develop a series of body models of children at various ages and of different Body Mass Index (BMI), to represent a range of normal variations in anatomy, using literature information and input from pediatric physicians. We will then modify our existing realistic phantoms of children of median size at the different standard ages (newborn, 1, 5, 10, and 15 year olds) to represent a number of body models that represent individuals of different size and stature and calculate organ doses for all of these models, using Monte Carlo transport methods. As new pediatric subjects are scanned, we will match each subject to the most similar NURBS model and report all organ doses and store this information for each subject. We will also match the 50 individual studies segmented with the most similar NURBS models and directly assess the difference between the organ doses from the direct calculations and those estimated from the nearest match individual, to understand the uncertainties in the day to day use of this approach. When completed and used regularly, this will allow characterization of organ and body radiation dose from a large population of pediatric subjects, for their own dose records, and for other uses, such as studies of medical subjects'population doses.

Public Health Relevance

In this project, we will use segmented images of a number of pediatric patients and literature resources to guide the development of a series of models of children of different size and age. We will use these models with radiation transport simulation software to calculate radiation doses for a broad range of routinely performed CT studies, so that subjects in the future who receive these studies can be assigned a reasonably accurate estimate of radiation dose to their organs, which can be saved to be part of a lifetime record of their radiation exposures.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA155400-03
Application #
8520258
Study Section
Special Emphasis Panel (ZRG1-DTCS-A (81))
Program Officer
Henderson, Lori A
Project Start
2011-08-05
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
3
Fiscal Year
2013
Total Cost
$232,500
Indirect Cost
$76,460
Name
Vanderbilt University Medical Center
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212