Cancer genetic testing alerts mutation carrier members to their elevated risk before disease onset, when early detection and even prevention may be possible. Little is known about the effect of genetic test reporting on prevention behaviors, as prior studies have focused on screening. Familial melanoma presents an ideal context in which to examine the impact of genetic test reporting on prevention behaviors because avoidance of UVR, a well-established risk factor in this population, represents a quantifiable prevention measure. We hypothesize that melanoma genetic test reporting will improve patient compliance with prevention and screening recommendations above that observed with counseling alone, and that specific cognitive and individual difference characteristics will be associated with compliance and non-compliance in the familial melanoma population. More broadly, our research strategy permits elucidation of cognitive processes that determine a patient's response to genetic test reporting. Thus, it may ultimately be possible to tailor genetic test results to maximize compliance with prevention recommendations. To accomplish these goals, four specific aims will be prospectively evaluated in 300 members of high-risk melanoma families.
In Aim 1 we will measure UVR exposure in unaffected mutation carriers, compared to counseling-only matched controls, using a wristwatch-type UVR dosimeter and reflectance spectroscopy device. This will allow us to disentangle the effects of counseling from those of genetic test reporting in the reduction of UVR exposure, our primary prevention outcome.
Aim 2 will similarly determine if counseling and/or reporting improve the frequency and thoroughness of skin self-examinations (SSEs) and professional total body skin examination (TBSEs).
Aim 3 will identify specific cognitive and emotional consequences of receiving a definitive positive genetic test result compared to counseling-only controls, and whether such changes mediate modification in prevention behaviors.
Aim 4 will identify patient subgroups at risk for poor adherence and psychological distress following reporting. Taken together, these Aims will allow determination of whether genetic test reporting improves prevention and screening adherence and if so, why and for whom.
The goal of predictive genetic testing for cancer is to alert carrier members of high-risk families to their elevated risk prior to the onset of disease, when early detection and even prevention may be possible. For such benefits to occur people who carry a genetic predisposition to cancer must understand their elevated risk and believe that prevention and screening efforts will be effective in managing their risk. The proposed study examines how a positive genetic test result influences high-risk participants'understanding and management of their melanoma risk over a two-year period, compared to participants who receive standard counseling based on family history alone.
|Wu, Yelena P; Aspinwall, Lisa G; Michaelis, Timothy C et al. (2016) Discussion of photoprotection, screening, and risk behaviors with children and grandchildren after melanoma genetic testing. J Community Genet 7:21-31|
|Wu, Yelena P; Aspinwall, Lisa G; Conn, Bridgid M et al. (2016) A systematic review of interventions to improve adherence to melanoma preventive behaviors for individuals at elevated risk. Prev Med 88:153-67|
|Wu, Yelena P; Aspinwall, Lisa G; Nagelhout, Elizabeth et al. (2016) Development of an Educational Program Integrating Concepts of Genetic Risk and Preventive Strategies for Children with a Family History of Melanoma. J Cancer Educ :|
|Aspinwall, Lisa G; Stump, Tammy K; Taber, Jennifer M et al. (2015) Impact of melanoma genetic test reporting on perceived control over melanoma prevention. J Behav Med 38:754-65|
|Taber, Jennifer M; Aspinwall, Lisa G; Stump, Tammy K et al. (2015) Genetic test reporting enhances understanding of risk information and acceptance of prevention recommendations compared to family history-based counseling alone. J Behav Med 38:740-53|
|Aspinwall, Lisa G; Taber, Jennifer M; Kohlmann, Wendy et al. (2014) Unaffected family members report improvements in daily routine sun protection 2 years following melanoma genetic testing. Genet Med 16:846-53|
|Aspinwall, Lisa G; Taber, Jennifer M; Kohlmann, Wendy et al. (2014) Perceived risk following melanoma genetic testing: a 2-year prospective study distinguishing subjective estimates from recall. J Genet Couns 23:421-37|
|Tanner, Paul; Leachman, Sancy; Boucher, Kenneth et al. (2014) Depigmented skin and phantom color measurements for realistic prostheses. Skin Res Technol 20:37-42|
|Aspinwall, Lisa G; Taber, Jennifer M; Leaf, Samantha L et al. (2013) Melanoma genetic counseling and test reporting improve screening adherence among unaffected carriers 2 years later. Cancer Epidemiol Biomarkers Prev 22:1687-97|
|Curtis, Julia; Tanner, Paul; Judd, Cambria et al. (2013) Acrylic nail curing UV lamps: high-intensity exposure warrants further research of skin cancer risk. J Am Acad Dermatol 69:1069-70|