Development, Application, and Evaluation of Prediction Models for Cancer Risk and Prognosis issued by the National Cancer Institute (NCI) supports research on innovative statistical methods for developing and evaluating new and existing cancer risk prediction models. Predictive accuracy is a key factor for determining clinical applicability of cancer risk prediction models in identifying high-risk individuals for ealy prevention. With continuously emerging risk factors for cancer, there is a pressing need for timely assessment of their added values for prediction. But study designs that balance cost and statistical efficiency and accompanying statistical methods are mostly lacking. This proposal responds to this PA by developing and evaluating cost-effective two-phase stratified case-control study designs and statistical inference methods for developing and evaluating absolute risk prediction models for cancer. Our proposed work is built on a popular method that integrates case-control data and external hazard rates of cancer and mortality to predict cancer absolute risk. As a showcase example for our statistical methods and accompanying software, we explore the added value of volumetric breast density for predicting breast cancer risk.
This project proposes to develop efficient study designs and statistical inference methods for developing and evaluating cancer absolute risk prediction models. Our methods, accompanied by a comprehensive and user-friendly software, will offer cancer researchers a rich arsenal of statistical tools for assessing the predictive potential of expensive candidate predictors under cost constraints.
|Chen, Lu; Weinberg, Clarice R; Chen, Jinbo (2016) Using family members to augment genetic case-control studies of a life-threatening disease. Stat Med 35:2815-30|
|Shen, Yuanyuan; Cai, Tianxi; Chen, Yu et al. (2015) Retrospective likelihood-based methods for analyzing case-cohort genetic association studies. Biometrics 71:960-8|
|McCarthy, Anne Marie; Keller, Brad; Kontos, Despina et al. (2015) The use of the Gail model, body mass index and SNPs to predict breast cancer among women with abnormal (BI-RADS 4) mammograms. Breast Cancer Res 17:1|
|Chai, Xinglei; Friebel, Tara M; Singer, Christian F et al. (2014) Use of risk-reducing surgeries in a prospective cohort of 1,499 BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 148:397-406|