This application directly addresses """"""""PQ13. Can tumors be detected when they are two to three orders of magnitude smaller than those currently detected with in vivo imaging modalities?"""""""" To date molecular imaging technologies have had limited clinical impact to date for a number of reasons. One of the primary ones is the inadequate contrast specificity of molecular contrast agents due to non-specific agent binding and background signals from tissue. Major increase in detection sensitivity would provide a fundamental change in how we diagnose and treat cancers. In this context, the overarching goal of this project is to develop an ultrasensitive platform technology based on a recent breakthrough we made on magnetomotion-based imaging-contrast enhancement (Nat. Commun. 2010). We have shown improvement of imaging S/N ratio of 3 orders or magnitude in phantoms by incorporating magnetic properties into imaging contrast agents. Through this project, we plan to further develop this innovative and powerful background suppression technique for in vivo tumor imaging and image-guided therapy. We will use photoacoustic imaging as a model, but the innovative concept and algorism can be expanded to virtually any other molecular imaging modalities involving contrast agents. This platform technology is also compatible with future major developments in the field of biomedical imaging, such as development of more specific probes and more sensitive detectors.

Public Health Relevance

The primary goal of this application is to develop an innovative, powerful, and flexible platform technology that can improve in vivo tumor imaging sensitivity by 2-3 orders of magnitude. Recent advances in molecular imaging have produced a number of outstanding agents and instruments, yet ultrasensitive detection of tumor in vivo has not been realized, which at least can be partially attributed to the strong background that obscure specific signals since what really matters is signal-to-noise ratio rather than absolute detection sensitivity. In this context, we propose to develop a new imaging strategy based on coupled contrast agents and magnetomotive imaging, which is capable of efficiently removing background for improved tumor detection limit.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA170734-03
Application #
8676751
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (M1))
Program Officer
Greenspan, Emily J
Project Start
2012-08-01
Project End
2016-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
$451,033
Indirect Cost
$159,102
Name
University of Washington
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Ambroziński, Łukasz; Song, Shaozhen; Yoon, Soon Joon et al. (2016) Acoustic micro-tapping for non-contact 4D imaging of tissue elasticity. Sci Rep 6:38967
Ambroziński, Łukasz; Pelivanov, Ivan; Song, Shaozhen et al. (2016) Air-coupled acoustic radiation force for non-contact generation of broadband mechanical waves in soft media. Appl Phys Lett 109:043701
Shang, Jing; Gao, Xiaohu (2015) Leveraging nanotechnology for enrichment of circulating tumor cells in vivo. Nanomedicine (Lond) 10:2477-80
Li, Junwei; Yoon, Soon Joon; Hsieh, Bao-Yu et al. (2015) Stably Doped Conducting Polymer Nanoshells by Surface Initiated Polymerization. Nano Lett 15:8217-22
Wei, Chen-Wei; Nguyen, Thu-Mai; Xia, Jinjun et al. (2015) Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide interventional procedures: ex vivo study. IEEE Trans Ultrason Ferroelectr Freq Control 62:319-28
Nguyen, Thu-Mai; Arnal, Bastien; Song, Shaozhen et al. (2015) Shear wave elastography using amplitude-modulated acoustic radiation force and phase-sensitive optical coherence tomography. J Biomed Opt 20:016001
Li, Junwei; Arnal, Bastien; Wei, Chen-Wei et al. (2015) Magneto-optical nanoparticles for cyclic magnetomotive photoacoustic imaging. ACS Nano 9:1964-76
Nguyen, Thu-Mai; Song, Shaozhen; Arnal, Bastien et al. (2014) Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography. J Biomed Opt 19:16013
Nguyen, Thu-Mai; Song, Shaozhen; Arnal, Bastien et al. (2014) Visualizing ultrasonically induced shear wave propagation using phase-sensitive optical coherence tomography for dynamic elastography. Opt Lett 39:838-41
Arnal, Bastien; Nguyen, Thu-Mai; O'Donnell, Matthew (2014) Toric focusing for radiation force applications using a toric lens coupled to a spherically focused transducer. IEEE Trans Ultrason Ferroelectr Freq Control 61:2032-41

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