About 60,000 individuals undergo surgery for lung cancer in the US annually. For these patients, whether, or not, cancer has spread to their lymph nodes is the main determinant of their prognosis and guides post- operative treatment decision-making. Unfortunately, most lung cancer operations done in the US do not provide a sufficient sample of lymph nodes to make an accurate determination of pathologic lymph node stage. Therefore, a larger number of patients die of lung cancer than would have been predicted by their post- operative stage. Examination of the quality of lung cancer surgical resections in the greater Memphis Metropolitan Area reveals close approximation to the US national quality-of-care gap. Deploying a specially designed lymph node specimen collection kit for use in lung cancer resections significantly improves the quality of pathologic lymph node staging and increases the detection of patients with lymph node metastasis. We now want to test the implementation of the routine use of this unique specimen collection kit in the tri-state area of Eastern Arkansas, Northern Mississippi and Western Tennessee, which has the combination of challenging socio-economic demographics and some of the highest lung cancer mortality rates in the US. Based on our prior work, we hypothesize that successful implementation of this surgical lymph node specimen collection kit will improve the quality of pathologic staging of lung cancer and increase the detection of lymph node metastasis in a diverse mix of patients operated on by a diverse mix of surgeons in a diverse mix of institutions. Our objective is to study the implementation process of routine use of this kit in a demographically diverse, high lung cancer incidence region of the US, in order to maximize its impact in future dissemination. We propose to achieve this by performing the following Specific Aims: 1.) Recruit at least 90% of eligible hospitals (those within our defined catchment area with >5 lung resection operations annually) and surgeons to participate in an implementation study of the lymph node specimen collection kit for lung cancer resections;2.) Evaluate the effectiveness of the kit in surgery performed in a diverse mix of institutions, using a staggered implementation, multiple baseline study design;3.) Study the implementation process using the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework. Our study will demonstrate the practical possibility of significantly improving the quality and outcomes of surgical lung cancer care across heterogeneity of practice settings. General improvement in pathologic staging will set the stage for future translational work on development of independently prognostic gene and protein expression profiles by optimizing the use of the Tumor, Node, and Metastasis (TNM) staging system, which is currently our best risk stratification system. The ultimate goal of this project i to provide the clinical infrastructure to support future studies of such prognostic molecular signatures that will supplement, and eventually supersede the current TNM staging system.

Public Health Relevance

This is a quality improvement project designed to examine the process of implementing the routine use of a special lymph node specimen collection kit. The goal is to improve the pathologic staging of surgically operable lung cancer in a high lung cancer incidence and mortality region of the US. This study uses a team-based approach involving multiple stakeholders, in an effort to improve the quality of surgical care for potentially curable lung cancer, the most commonly lethal cancer worldwide and in the U.S.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
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Study Section
Dissemination and Implementation Research in Health Study Section (DIRH)
Program Officer
Breen, Nancy
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University of Memphis
Schools of Public Health
United States
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Smeltzer, Matthew P; Faris, Nicholas; Yu, Xinhua et al. (2016) Missed Intrapulmonary Lymph Node Metastasis and Survival After Resection of Non-Small Cell Lung Cancer. Ann Thorac Surg 102:448-53
Osarogiagbon, Raymond U; Decker, Paul A; Ballman, Karla et al. (2016) Survival Implications of Variation in the Thoroughness of Pathologic Lymph Node Examination in American College of Surgeons Oncology Group Z0030 (Alliance). Ann Thorac Surg 102:363-9
Osarogiagbon, Raymond U; Lin, Chun Chieh; Smeltzer, Matthew P et al. (2016) Prevalence, Prognostic Implications, and Survival Modulators of Incompletely Resected Non-Small Cell Lung Cancer in the U.S. National Cancer Data Base. J Thorac Oncol 11:e5-16
Osarogiagbon, Raymond U (2016) Improving post-resection risk stratification in non-small cell lung cancer: 'wit, whither wander you?' J Thorac Dis 8:2315-2318
Levy, Marian; Gentry, Daniel; Klesges, Lisa M (2015) Innovations in public health education: promoting professional development and a culture of health. Am J Public Health 105 Suppl 1:S44-5
Osarogiagbon, Raymond U; Hilsenbeck, Holly L; Sales, Elizabeth W et al. (2015) Improving the pathologic evaluation of lung cancer resection specimens. Transl Lung Cancer Res 4:432-7
Alcántara, Carmela; Klesges, Lisa M; Resnicow, Ken et al. (2015) Enhancing the Evidence for Behavioral Counseling: A Perspective From the Society of Behavioral Medicine. Am J Prev Med 49:S184-93
Osarogiagbon, Raymond U; D'Amico, Thomas A (2015) Improving lung cancer outcomes by improving the quality of surgical care. Transl Lung Cancer Res 4:424-31
Yu, Xinhua; Klesges, Lisa M; Smeltzer, Mathew P et al. (2015) Measuring improvement in populations: implementing and evaluating successful change in lung cancer care. Transl Lung Cancer Res 4:373-84
Osarogiagbon, Raymond U; Sareen, Srishti; Eke, Ransome et al. (2015) Audit of lymphadenectomy in lung cancer resections using a specimen collection kit and checklist. Ann Thorac Surg 99:421-7

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