The objective of this methods proposal is to develop and apply new statistical methods to improve scientific inferences on the disease attribution associated with risk factors, such as obesity and tobacco smoking, for data collected from longitudinal cohort studies in chronic disease prevention research, specifically aiming to: (1) develop general statistical methods for time-varying attributable risk functions (ARF) to assess and compare prevention strategies;(2) develop statistical methods for a set of pairwise ARF's to assess and identify practically optimal prevention strategies;(3) develop statistical methods to evaluate the disease attribution in residual time;(4) develop statistical software and apply the developed methods to a large collection of cohort data from the Asia Cohort Consortium.

Public Health Relevance

This application aims to develop new statistical tools to analyze the time-varying disease attribution for longitudinal cohort studies in chronic disease prevention research. Its overall public health impact lies in applying these new tools to improve our understanding of the health implications of prevention strategies in translational research and clinical care.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA172415-01A1
Application #
8577058
Study Section
Epidemiology of Cancer Study Section (EPIC)
Program Officer
Mariotto, Angela B
Project Start
2013-09-30
Project End
2017-07-31
Budget Start
2013-09-30
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$355,251
Indirect Cost
$147,751
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Crouch, Luis Alexander; May, Susanne; Chen, Ying Qing (2016) On estimation of covariate-specific residual time quantiles under the proportional hazards model. Lifetime Data Anal 22:299-319
Safren, Steven A; Mayer, Kenneth H; Ou, San-San et al. (2015) Adherence to Early Antiretroviral Therapy: Results From HPTN 052, a Phase III, Multinational Randomized Trial of ART to Prevent HIV-1 Sexual Transmission in Serodiscordant Couples. J Acquir Immune Defic Syndr 69:234-40
Grant, Shannon; Chen, Ying Qing; May, Susanne (2014) Performance of goodness-of-fit tests for the Cox proportional hazards model with time-varying covariates. Lifetime Data Anal 20:355-68
Saegusa, Takumi; Di, Chongzhi; Chen, Ying Qing (2014) Hypothesis testing for an extended cox model with time-varying coefficients. Biometrics 70:619-28