Proposed is the combining of tumor-targeted, biocompatible, contrast enabling nanoparticles with photoacoustic imaging (PAI). PAI is an emerging, simple, low cost, non-ionizing and non-invasive method.
The aim of this combination is to achieve simultaneous structural and chemical/functional imaging. Recently, the emerging PAI technique has drawn considerable attention and has been explored for its potential application to a variety of diseases, including breast cancer, prostate cancer, melanoma and inflammatory arthritis. The proposed nanosonophore-based PAI method enables safe imaging, using only light and ultrasound, together with biocompatible, hydrogel-based, biodegradable and bio-eliminable nanoparticle contrast agents and sensors. The resultant non-invasive and non-ionizing PAI will enable morphological and functional evaluation, across the tumor, with both high spatial and high temporal resolution, but without any damage to the tissues. Currently no gold standard exists for such functional imaging. The proposed imaging method can be used for early detection and diagnosis of tumors, and for monitoring the progression of disease and of therapy. It could also observe phenomena at the molecular level in vivo and allow a better understanding of the pathophysiology of diseases as well as of disease onset, progression, and response to therapy. Using a nanoparticle contrast agent that enables multiple chemical and structural imaging functions, simultaneously, will free healthcare practitioners from having to perform a series of examinations with a diverse set of contrast agents so as to generate a complete diagnostic assessment.
The Specific Aims are: 1. Optimization of Targeted Multi-functional Sonophoric Nanoparticles (NPs) as Contrast Agents for in-vivo Structural and Functional Photoacoustic Imaging. 2. Structural Imaging using Nanoparticles Targeted at the Tumor 3. Functional Imaging of the In-Vivo Distribution of Oxygen and pH Across Tumors. 4. Monitoring Tumor Therapy by a Combination of Structural and Functional Imaging.

Public Health Relevance

Proposed is a combination of tumor-targeted, biocompatible nanoparticles with the emerging simple and inexpensive, non-ionizing and non-invasive, photo-acoustic imaging (PAI) method, so as to achieve simultaneous physical and chemical imaging. The approach can be used for early detection and diagnosis of tumors, as well as for monitoring the progression of disease and therapy. Using a nanoparticle contrast agent that enables multiple chemical and physical imaging functions, healthcare practitioners would not have to perform a series of examinations with a diverse set of contrast agents so as to generate a complete diagnostic assessment.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA186769-05
Application #
9438375
Study Section
Nanotechnology Study Section (NANO)
Program Officer
Tandon, Pushpa
Project Start
2014-04-02
Project End
2019-02-28
Budget Start
2018-03-01
Budget End
2019-02-28
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Lee, Chang H; Folz, Jeff; Zhang, Wuliang et al. (2017) Ion-Selective Nanosensor for Photoacoustic and Fluorescence Imaging of Potassium. Anal Chem 89:7943-7949
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Jo, Janggun; Lee, Chang Heon; Kopelman, Raoul et al. (2016) Lifetime-resolved Photoacoustic (LPA) Spectroscopy for monitoring Oxygen change and Photodynamic Therapy (PDT). Proc SPIE Int Soc Opt Eng 9708:
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