Cachexia is a metabolic wasting syndrome that commonly affects cancer patients, and accounts for as many as 25% of cancer deaths. The root causes of cancer cachexia remain unknown, and as such there are presently no effective treatments for the disorder. We have developed the first-ever experimental system to study cancer cachexia, and we therefore propose here to use the system to discover the proteins secreted by tumors that cause the cachexia phenotype. We will use advanced proteomic approaches to identify high priority candidate proteins, and we will further validate those candidates based on their differential abundance in patient-derived plasma samples, and we will functionally validate them both in vitro and in vivo. These studies are expected to lead to the discovery of the biological basis of cachexia, and thereby establish a clear path toward the development of effective therapeutics.

Public Health Relevance

Cancer patients often suffer from a metabolic syndrome that involves muscle and fat wasting and in many cases results in early death. Here we propose to discover the root cause of cancer cachexia. Once the cause of cachexia is understood, the development of effective treatments will be straightforward.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA190101-02
Application #
8928585
Study Section
Special Emphasis Panel (ZCA1-GRB-I (A1))
Program Officer
Spalholz, Barbara A
Project Start
2014-09-17
Project End
2018-08-31
Budget Start
2015-09-01
Budget End
2016-08-31
Support Year
2
Fiscal Year
2015
Total Cost
$615,301
Indirect Cost
$209,547
Name
Broad Institute, Inc.
Department
Type
DUNS #
623544785
City
Cambridge
State
MA
Country
United States
Zip Code
02142