The goal of this line of research is to develop and evaluate interventions that maintain nonsmoking, and in so doing, better understand the processes leading to smoking cessation and relapse. This is a competing continuation application for a line of research that has produced 42 journal articles, 18 book chapters, and 27 abstracts over a 20-year period. Certain population subgroups are at risk for continued smoking and relapse; one subgroup is smokers 50+ years of age, who are increasing in number as the general population ages. Smoking is a serious health risk factor for older individuals. Smoking cessation dramatically reduces mortality and morbidity from cancer, cardiac disease, and other illnesses in this age group. Recent practice guidelines call for research on pharmacological strategies for smokers 50+ years. Data indicates that these smokers are highly nicotine dependent and have a high prevalence of """"""""subsyndromal depression."""""""" Our group has worked extensively with nicotine dependent and depressed smokers. This earlier work will be used to inform an innovative intervention. Thus, the specific aims of the proposed work are to test a series of hypotheses about the efficacy and cost-effectiveness of four interventions for older smokers. Participants (N=432) will be randomly assigned to one of four intervention conditions: (1) counseling control; (2) standard (12 week) Nicotine Replacement Therapy (NRT); (3) extended (52 week) psychosocial support/standard NRT; (4) extended psychosocial support/extended (52 week) NRT. Participants will be assessed at baseline on smoking, nicotine dependence, diagnosis, demographics, mood, social support, health status, motivation for change, and drug and alcohol use. At weeks 12, 24, 36, 52 and 104, participants will be assessed on self-reports of smoking verified by carbon monoxide and anatabine/anabasine, and measures of mood, social support, health status and motivation for change. Urinary cotinine will be collected at week 104. The prototypical data analysis strategy is GEE. Also, we will complete exploratory analyses to determine those variables that best predict smoking treatment outcome, and differential response to the extended interventions in older smokers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA002538-25
Application #
7022984
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Grossman, Debra
Project Start
2001-09-30
Project End
2009-02-28
Budget Start
2006-03-01
Budget End
2009-02-28
Support Year
25
Fiscal Year
2006
Total Cost
$466,574
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Leyro, Teresa M; Crew, Erin E; Bryson, Susan W et al. (2016) Retrospective analysis of changing characteristics of treatment-seeking smokers: implications for further reducing smoking prevalence. BMJ Open 6:e010960
Farabee, David; Hawken, Angela; Calhoun, Stacy et al. (2016) Tracking and Locating Itinerant Subjects With a Rechargeable Incentive Card: Results of a Randomized Trial. Subst Use Misuse 51:658-63
Hall, Sharon M; Shi, Yanling; Humfleet, Gary L et al. (2015) Smoking cessation abstinence goal in treatment-seeking smokers. Addict Behav 42:148-53
Leyro, Teresa M; Hendricks, Peter S; Hall, Sharon M (2015) If at first you don't succeed: characterization of smokers with late smoking abstinence onset. Addict Behav 45:34-8
Grady, Eric S; Humfleet, Gary L; Delucchi, Kevin L et al. (2014) Smoking cessation outcomes among sexual and gender minority and nonminority smokers in extended smoking treatments. Nicotine Tob Res 16:1207-15
Barnett, Paul G; Wong, Wynnie; Jeffers, Abra et al. (2014) Cost-effectiveness of extended cessation treatment for older smokers. Addiction 109:314-22
Humfleet, Gary L; Hall, Sharon M; Delucchi, Kevin L et al. (2013) A randomized clinical trial of smoking cessation treatments provided in HIV clinical care settings. Nicotine Tob Res 15:1436-45
Hendricks, Peter S; Delucchi, Kevin L; Humfleet, Gary L et al. (2012) Alcohol and marijuana use in the context of tobacco dependence treatment: impact on outcome and mediation of effect. Nicotine Tob Res 14:942-51
Hall, Sharon M; Humfleet, Gary L; Munoz, Ricardo F et al. (2011) Using extended cognitive behavioral treatment and medication to treat dependent smokers. Am J Public Health 101:2349-56
Hendricks, Peter S; Wood, Sabrina B; Baker, Majel R et al. (2011) The Smoking Abstinence Questionnaire: measurement of smokers' abstinence-related expectancies. Addiction 106:716-28

Showing the most recent 10 out of 53 publications