This is an epidemiological study of the effects of prenatal marijuana consumption on offspring. It represents a unique opportunity to explore this relationship in a cohort of women and their children who currently are being studied during pregnancy and through the eighth postpartum month. We propose to extend the study to assess the children at 18 months and 3 years of age. Growth parameters, morphological characteristics and neurological status will be assessed at each time point. Developmental status and behavioral characteristics will be measured using age-appropriate instruments. This study will: (1) Assess the effects of maternal marijuana use during pregnancy on the long-term physical development and morphological characteristics of children. (2) Examine the developmental status and behavioral characteristics of these children at 18 months and 3 years. (3) Determine differences in electroencephalographic patterns and sleep organization in these children. Careful assessment of sociodemographic characteristics, life style, other drug use and psychiatric symptom levels allows us to separate the direct teratogenic effect of marijuana use from the contributing effects of other factors that accompany marijuana use. Instruments and procedures from the prenatal periods through the eight-month postpartum assessment have been developed, tested and implemented.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA003874-06
Application #
3208654
Study Section
Special Emphasis Panel (SRCD (08))
Project Start
1986-09-01
Project End
1993-05-31
Budget Start
1991-12-01
Budget End
1993-05-31
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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De Genna, Natacha M; Goldschmidt, Lidush; Day, Nancy L et al. (2016) Prenatal and Postnatal Maternal Trajectories of Cigarette Use Predict Adolescent Cigarette Use. Nicotine Tob Res 18:988-92
Diesel, Jill C; Bodnar, Lisa M; Day, Nancy L et al. (2016) Childhood maltreatment and the risk of pre-pregnancy obesity and excessive gestational weight gain. Matern Child Nutr 12:558-68
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De Genna, Natacha M; Cornelius, Marie D; Goldschmidt, Lidush et al. (2015) Maternal age and trajectories of cannabis use. Drug Alcohol Depend 156:199-206
Diesel, J C; Eckhardt, C L; Day, N L et al. (2015) Gestational weight gain and the risk of offspring obesity at 10 and 16 years: a prospective cohort study in low-income women. BJOG 122:1395-402
Sonon, Kristen E; Richardson, Gale A; Cornelius, Jack R et al. (2015) Prenatal marijuana exposure predicts marijuana use in young adulthood. Neurotoxicol Teratol 47:10-5
Diesel, Jill C; Eckhardt, Cara L; Day, Nancy L et al. (2015) Gestational Weight Gain and Offspring Longitudinal Growth in Early Life. Ann Nutr Metab 67:49-57
Diesel, J C; Eckhardt, C L; Day, N L et al. (2015) Is gestational weight gain associated with offspring obesity at 36 months? Pediatr Obes 10:305-10

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