Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA005158-09
Application #
2117477
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Program Officer
Lin, Geraline
Project Start
1988-04-01
Project End
1998-08-31
Budget Start
1996-03-01
Budget End
1998-08-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Physiology
Type
Schools of Medicine
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Jamali, Khalid; Naylor, Barry R; Kelly, Martin J et al. (2003) Effect of 17beta-estradiol on mRNA expression of large- conductance, voltage-dependent, and calcium-activated potassium channel alpha and beta subunits in guinea pig. Endocrine 20:227-37
Lagrange, A H; Ronnekleiv, O K; Kelly, M J (1995) Estradiol-17 beta and mu-opioid peptides rapidly hyperpolarize GnRH neurons: a cellular mechanism of negative feedback? Endocrinology 136:2341-4
Thornton, J E; Loose, M D; Kelly, M J et al. (1994) Effects of estrogen on the number of neurons expressing beta-endorphin in the medial basal hypothalamus of the female guinea pig. J Comp Neurol 341:68-77
Lagrange, A H; Ronnekleiv, O K; Kelly, M J (1994) The potency of mu-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17 beta-estradiol. J Neurosci 14:6196-204
Erickson, K R; Ronnekleiv, O K; Kelly, M J (1993) Electrophysiology of guinea-pig supraoptic neurones: role of a hyperpolarization-activated cation current in phasic firing. J Physiol 460:407-25
Erickson, K R; Ronnekleiv, O K; Kelly, M J (1993) Role of a T-type calcium current in supporting a depolarizing potential, damped oscillations, and phasic firing in vasopressinergic guinea pig supraoptic neurons. Neuroendocrinology 57:789-800
Kelly, M J; Loose, M D; Ronnekleiv, O K (1992) Estrogen suppresses mu-opioid- and GABAB-mediated hyperpolarization of hypothalamic arcuate neurons. J Neurosci 12:2745-50
Loose, M D; Ronnekleiv, O K; Kelly, M J (1991) Neurons in the rat arcuate nucleus are hyperpolarized by GABAB and mu-opioid receptor agonists: evidence for convergence at a ligand-gated potassium conductance. Neuroendocrinology 54:537-44
Loose, M D; Ronnekleiv, O K; Kelly, M J (1990) Membrane properties and response to opioids of identified dopamine neurons in the guinea pig hypothalamus. J Neurosci 10:3627-34
Kelly, M J; Loose, M D; Ronnekleiv, O K (1990) Opioids hyperpolarize beta-endorphin neurons via mu-receptor activation of a potassium conductance. Neuroendocrinology 52:268-75

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