Two studies are proposed to examine electrophysiological and neuropsychological test performance in recovering substance abusers. Study #1 will examine 30 cocaine dependent and 30 alcohol dependent patients after 2-4 and 8-10 months of verified abstinence. Study #2 will examine 2 groups of methadone-maintained patients with recent (2-4 months) or without histories of cocaine dependence. As a secondary goal, Study #2 will also compare methadone-dependent patients in the early asymptomatic stages of HIV-1 infection of those without infection. It will also allow examination of the potential additive or interactive effects of current HIV infection and previous cocaine dependence. The test battery will include several measures from our current battery, e.g., tremor, smooth pursuit and saccadic eye movements, EEG photic driving responses. Several new measures will also be added to assess sensory function (SEP, ABR, PRVEP) and higher level cognitive abilities, such as cognitive flexibility and short term memory. The same measures will be recorded from groups of non-drug-dependent, age- and education- matched controls. The resultant data will be useful for describing the nature, severity, and persistence of neuropsychological/electrophysiological impairments in recovering cocaine dependent patients. The data will also identify subgroups of cocaine dependent patients who may be at greatest neuropsychological risk, due to opiate dependence and/or HIV infection.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA005826-09
Application #
2443430
Study Section
Special Emphasis Panel (SRCD (52))
Project Start
1989-04-01
Project End
2000-06-30
Budget Start
1997-07-01
Budget End
2000-06-30
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030
Bauer, Lance O; Hesselbrock, Victor M (2003) Brain maturation and subtypes of conduct disorder: interactive effects on p300 amplitude and topography in male adolescents. J Am Acad Child Adolesc Psychiatry 42:106-15
Bauer, Lance O (2002) Differential effects of alcohol, cocaine, and opioid abuse on event-related potentials recorded during a response competition task. Drug Alcohol Depend 66:137-45
Bauer, L O (2001) Predicting relapse to alcohol and drug abuse via quantitative electroencephalography. Neuropsychopharmacology 25:332-40
Bauer, L O (2001) CNS recovery from cocaine, cocaine and alcohol, or opioid dependence: a P300 study. Clin Neurophysiol 112:1508-15
Bauer, L O (2001) Antisocial personality disorder and cocaine dependence: their effects on behavioral and electroencephalographic measures of time estimation. Drug Alcohol Depend 63:87-95
Stevens, M C; Kaplan, R F; Bauer, L O (2001) Relationship of cognitive ability to the developmental course of antisocial behavior in substance-dependent patients. Prog Neuropsychopharmacol Biol Psychiatry 25:1523-36
Deckel, A W; Cohen, D (2000) Increased CBF velocity during word fluency in Huntington's disease patients. Prog Neuropsychopharmacol Biol Psychiatry 24:193-206
Bauer, L O; Hesselbrock, V M (1999) P300 decrements in teenagers with conduct problems: implications for substance abuse risk and brain development. Biol Psychiatry 46:263-72
Wehr, A; Bauer, L O (1999) Verbal ability predicts abstinence from drugs and alcohol in a residential treatment population. Psychol Rep 84:1354-60
Bauer, L O; Hesselbrock, V M (1999) Subtypes of family history and conduct disorder: effects on P300 during the stroop test. Neuropsychopharmacology 21:51-62

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