Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA006662-06
Application #
2118859
Study Section
Sociobehavioral Subcommittee (DAAR)
Program Officer
Sharp, Charles
Project Start
1991-06-01
Project End
1998-02-28
Budget Start
1996-05-01
Budget End
1998-02-28
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Soderberg, L S F; Ponnappan, U; Roy, A et al. (2004) Production of macrophage IL-1beta was inhibited both at the levels of transcription and maturation by caspase-1 following inhalation exposure to isobutyl nitrite. Toxicol Lett 152:47-56
Ponnappan, Usha; Yull, Fiona E; Soderberg, Lee S F (2004) Inhaled isobutyl nitrite inhibited macrophage inducible nitric oxide by blocking NFkappaB signaling and promoting degradation of inducible nitric oxide synthase-2. Int Immunopharmacol 4:1075-82
Soderberg, Lee S F; Ponnappan, Usha (2002) Cytotoxicity by nitrite inhalants is not related to peroxynitrite formation. Toxicol Lett 132:37-45
Ponnappan, U; Soderberg, L S (2001) Inflammatory macrophage nuclear factor-kappaB and proteasome activity are inhibited following exposure to inhaled isobutyl nitrite. J Leukoc Biol 69:639-44
Guo, G L; Rose, D; Flick, J T et al. (2000) Acute exposure to the abused inhalant, isobutyl nitrite, reduced T cell responsiveness and spleen cellularity. Toxicol Lett 116:151-8
Soderberg, L S; Roy, A; Flick, J T et al. (2000) Nitrite inhalants spontaneously liberate nitric oxide, which is not responsible for the immunotoxicity in C57BL/6 mice. Int J Immunopharmacol 22:151-7
Soderberg, L S (1999) Increased tumor growth in mice exposed to inhaled isobutyl nitrite. Toxicol Lett 104:35-41
Soderberg, L S; Flick, J T (1997) Acute blood toxicity of the abused inhalant, cyclohexyl nitrite. Int J Immunopharmacol 19:305-10
Soderberg, L S; Flick, J T; Barnett, J B (1996) Leukopenia and altered hematopoietic activity in mice exposed to the abused inhalant, isobutyl nitrite. Exp Hematol 24:848-53
Soderberg, L S; Flick, J T; Barnett, J B (1996) Acute inhalation exposure to isobutyl nitrite causes nonspecific blood cell destruction. Exp Hematol 24:592-6

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