The proposed revised application would continue research on a sample of 999 multiethnic adults who were longitudinally assessed from ages 11-12 to 23-24. Assessment included a CIDI diagnostic interview at age 18-19 and coded videotaped observations of adolescent family and peer interactions. The sample was individually randomized to the Family Check-Up model in adolescence, which yielded long-term effects on drug use, antisocial behavior, depression, and academic success. The proposed follow-up assessment at age 26- 27 would include the CIDI diagnostic interview on addictive behavior and psychopathology, time allocation to high- versus low-investment activities, peer network, self-regulation, and the collection of DNA in saliva samples. Three approaches to genotyping are proposed, including candidate gene, gene family, and novel gene exploration by a team of investigators currently studying the molecular genetics of addictive behavior. These data will be used to address the following hypotheses: (a) the disrupted self-regulation hypothesis, that adult problem behavior generally and addictive behavior specifically are part of an overall pattern of adaptation that is characterized by a low-investment strategy in respect to family relationships and other adult milestones, with low demands on self-regulation;(b) the genetic moderation hypothesis, indicating that the effects of poor parental monitoring and deviant peer exposure on progressions in AOD use and other problem behaviors are most pronounced for youth who are genetically vulnerable;and (c) the risk malleability hypothesis, which proposes that early environmental risk can be modified and that these effects are especially pronounced for genetically prone youth. Testing of all 3 sets of hypotheses requires examination of longitudinal data from early adolescence through age 26-27 that uses a variety of advanced analytic strategies, including trajectory analyses, latent profile analysis, latent growth modeling, and complier average causal effect modeling for examining the effects of the Family Check-Up on risk exposure.

Public Health Relevance

This application proposes a follow-up assessment at age 26-27 of 999 multiethnic, urban youth who had been involved in a longitudinal randomized controlled prevention trial of a family-centered intervention beginning at age 11, which will include strong measurement of the parenting and peer environment and genetic vulnerability. The study proposes to consider the joint role of genetic and environmental factors on the progression of adult AOD use, antisocial and high-risk sexual behavior, and the response of identified risk processes to family intervention. The research will lead to a better understanding of the risk and protective mechanisms, malleability of those mechanisms, and the design of more precise and innovative strategies for prevention and treatment of adult AOD and other problem behaviors.

National Institute of Health (NIH)
Research Project (R01)
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Risk, Prevention and Intervention for Addictions Study Section (RPIA)
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Crump, Aria
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Arizona State University-Tempe Campus
Schools of Arts and Sciences
United States
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Piehler, Timothy F; Dishion, Thomas J (2014) Dyadic coregulation and deviant talk in adolescent friendships: interaction patterns associated with problematic substance use in early adulthood. Dev Psychol 50:1160-9
Smith, Justin D; Knoble, Naomi B; Zerr, Argero A et al. (2014) Family check-up effects across diverse ethnic groups: reducing early-adolescence antisocial behavior by reducing family conflict. J Clin Child Adolesc Psychol 43:400-14
Dishion, Thomas J; Kim, Hanjoe; Stormshak, Elizabeth A et al. (2014) A brief measure of peer affiliation and social acceptance (PASA): validity in an ethnically diverse sample of early adolescents. J Clin Child Adolesc Psychol 43:601-12
Véronneau, Marie-Hélène; Racer, Kristina Hiatt; Fosco, Gregory M et al. (2014) The Contribution of Adolescent Effortful Control to Early Adult Educational Attainment. J Educ Psychol 106:730-743
Van Ryzin, Mark J; Nowicka, Paulina (2013) Direct and indirect effects of a family-based intervention in early adolescence on parent-youth relationship quality, late adolescent health, and early adult obesity. J Fam Psychol 27:106-16
Van Ryzin, Mark J; Dishion, Thomas J (2013) From antisocial behavior to violence: a model for the amplifying role of coercive joining in adolescent friendships. J Child Psychol Psychiatry 54:661-9
Poulin, Francois; Kiesner, Jeff; Pedersen, Sara et al. (2011) A short-term longitudinal analysis of friendship selection on early adolescent substance use. J Adolesc 34:249-56
Dishion, Thomas J; Tipsord, Jessica M (2011) Peer contagion in child and adolescent social and emotional development. Annu Rev Psychol 62:189-214
Wang, Ming-Te; Dishion, Thomas J; Stormshak, Elizabeth A et al. (2011) Trajectories of family management practices and early adolescent behavioral outcomes. Dev Psychol 47:1324-41
Boislard P, Marie-Aude; Poulin, Francois (2011) Individual, familial, friends-related and contextual predictors of early sexual intercourse. J Adolesc 34:289-300

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