Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA007259-05
Application #
2119637
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1991-12-15
Project End
1999-12-31
Budget Start
1996-02-01
Budget End
1996-12-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Zhang, Yuan-Wei; Tavoulari, Sotiria; Sinning, Steffen et al. (2018) Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT. Proc Natl Acad Sci U S A 115:E8854-E8862
Tavoulari, Sotiria; Margheritis, Eleonora; Nagarajan, Anu et al. (2016) Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog. J Biol Chem 291:1456-71
Sandtner, Walter; Stockner, Thomas; Hasenhuetl, Peter S et al. (2016) Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters. Mol Pharmacol 89:165-75
Zhang, Yuan-Wei; Turk, Benjamin E; Rudnick, Gary (2016) Control of serotonin transporter phosphorylation by conformational state. Proc Natl Acad Sci U S A 113:E2776-83
Fenollar-Ferrer, Cristina; Stockner, Thomas; Schwarz, Thomas C et al. (2014) Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter. Biochemistry 53:5444-60
Rudnick, Gary; Krämer, Reinhard; Blakely, Randy D et al. (2014) The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch 466:25-42
Porton, B; Greenberg, B D; Askland, K et al. (2013) Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder. Transl Psychiatry 3:e259
Rudnick, Gary (2013) How do transporters couple solute movements? Mol Membr Biol 30:355-9
Schicker, Klaus; Uzelac, Zeljko; Gesmonde, Joan et al. (2012) Unifying concept of serotonin transporter-associated currents. J Biol Chem 287:438-45
Bulling, Simon; Schicker, Klaus; Zhang, Yuan-Wei et al. (2012) The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. J Biol Chem 287:18524-34

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