This is a resubmission of a competing renewal of RO1 DA08425, Serotonin and Aggression in Cocaine Dependence. The title of renewal has been changed to reflect the newly defined emphasis on the impact of impulsivity on the treatment of cocaine dependence. Cocaine Dependence is associated with higher levels of impulsivity, both clinically and as measured by questionnaires and laboratory measures. We have found that impulsivity is associated with a poor outcome in the treatment of cocaine dependence. Further, there is evidence from our group and others that impulsivity is associated with decreased functioning of the neurotransmitter serotonin, and that serotonergic medication increases response to contingency management treatment for cocaine dependence. In light of the above data, we propose a treatment study to determine whether the serotonin reuptake inhibitor citalopram improves response to contingency management treatment of cocaine dependence. We also propose to measure serotonin and impulsivity to determine whether baseline serotonin function, and changes in impulsivity predict response to treatment.
The Specific Aims of this proposal are:
Aim 1. To determine whether chronic administration of the 5-HT re-uptake inhibitor citalopram improves response to contingency management treatment of cocaine dependence.
Aim 2. To measure pretreatment Serotonin (5-HT) function using a citalopram neuroendocrine challenge and determine the relationship between 5-HT function and response to treatment in cocaine dependent subjects.
Aim 3. To measure impulsivity in subjects undergoing treatment for cocaine dependence using laboratory tasks to determine if changes in impulsivity predict response to treatment for cocaine dependence.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA008425-06
Application #
6515506
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Gordon, Harold
Project Start
1996-09-20
Project End
2005-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
6
Fiscal Year
2002
Total Cost
$296,126
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Lijffijt, Marijn; Cox, Blake; Acas, Michelle D et al. (2012) Differential relationships of impulsivity or antisocial symptoms on P50, N100, or P200 auditory sensory gating in controls and antisocial personality disorder. J Psychiatr Res 46:743-50
Swann, Alan C; Lijffijt, Marijn; Lane, Scott D et al. (2011) Interacting mechanisms of impulsivity in bipolar disorder and antisocial personality disorder. J Psychiatr Res 45:1477-82
Swann, Alan C; Lijffijt, Marijn; Lane, Scott D et al. (2011) Criminal conviction, impulsivity, and course of illness in bipolar disorder. Bipolar Disord 13:173-81
Swann, A C; Lijffijt, M; Lane, S D et al. (2010) Interactions between bipolar disorder and antisocial personality disorder in trait impulsivity and severity of illness. Acta Psychiatr Scand 121:453-61
Green, C E; Moeller, F G; Schmitz, J M et al. (2009) Evaluation of heterogeneity in pharmacotherapy trials for drug dependence: a Bayesian approach. Am J Drug Alcohol Abuse 35:95-102
Lijffijt, Marijn; Moeller, F Gerard; Boutros, Nash N et al. (2009) Diminished P50, N100 and P200 auditory sensory gating in bipolar I disorder. Psychiatry Res 167:191-201
Lijffijt, Marijn; Moeller, F Gerard; Boutros, Nash N et al. (2009) The Role of Age, Gender, Education, and Intelligence in P50, N100, and P200 Auditory Sensory Gating. J Psychophysiol 23:52-62
Swann, Alan C; Lijffijt, Marijn; Lane, Scott D et al. (2009) Severity of bipolar disorder is associated with impairment of response inhibition. J Affect Disord 116:30-6
Lijffijt, Marijn; Moeller, F Gerard; Boutros, Nash N et al. (2009) A pilot study revealing impaired P50 gating in antisocial personality disorder. J Neuropsychiatry Clin Neurosci 21:328-31
Schmitz, Joy M; Mooney, Marc E; Green, Charles E et al. (2009) Baseline neurocognitive profiles differentiate abstainers and non-abstainers in a cocaine clinical trial. J Addict Dis 28:250-7

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