Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA008904-02
Application #
2121737
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1995-02-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Organix, Inc.
Department
Type
DUNS #
City
Woburn
State
MA
Country
United States
Zip Code
01801
Breivogel, Christopher S; Puri, Vanita; Lambert, Jonathan M et al. (2013) The influence of beta-arrestin2 on cannabinoid CB1 receptor coupling to G-proteins and subcellular localization and relative levels of beta-arrestin1 and 2 in mouse brain. J Recept Signal Transduct Res 33:367-79
Bisogno, Tiziana; Burston, James J; Rai, Ravi et al. (2009) Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. ChemMedChem 4:946-50
Breivogel, Christopher S; Lambert, Jonathan M; Gerfin, Steven et al. (2008) Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice. Behav Pharmacol 19:298-307
Bourne, Caryl; Roy, Sucharita; Wiley, Jenny L et al. (2007) Novel, potent THC/anandamide (hybrid) analogs. Bioorg Med Chem 15:7850-64
Bisogno, Tiziana; Cascio, Maria Grazia; Saha, Bijali et al. (2006) Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. Biochim Biophys Acta 1761:205-12
Wiley, Jenny L; Razdan, Raj K; Martin, Billy R (2006) Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice. Life Sci 80:24-35
Ligresti, Alessia; Cascio, Maria Grazia; Pryce, Gareth et al. (2006) New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis. Br J Pharmacol 147:83-91
Kaplan, Barbara L F; Ouyang, Yanli; Herring, Amy et al. (2005) Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2'-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide. Toxicol Appl Pharmacol 205:107-15
Vandevoorde, Severine; Saha, Bijali; Mahadevan, Anu et al. (2005) Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase. Biochem Biophys Res Commun 337:104-9
Wiley, Jenny L; Smith, Forrest L; Razdan, Raj K et al. (2005) Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice. Eur J Pharmacol 510:59-68

Showing the most recent 10 out of 19 publications