The long-term development of female substance use, substance-related problems, and substance use disorders (SUDs) is poorly understood. In at least two ways, females appear more vulnerable to substance abuse and dependence compared to males: they demonstrate more rapid development from onset of use to SUD, and a higher propensity to develop comorbid psychopathology. In addition, early onset of substance use carries a higher risk of developing an SUD among females compared with males. The main goal of the proposed research is to investigate the early phases in the development towards frequent substance use, substance-related problems, and SUD. This proposal describes a substudy to the NIMH-funded Pittsburgh Girls Study (N = 2,451;52% African-American, 41% Caucasian), an investigation of the development of antisocial behavior and delinquency in four age cohorts of girls, initially assessed at ages 5 to 8. The main study is now in its fifth yearly assessment (ages 9 to 12), and will continue for another 4 years. The proposed study requests a continuation of earlier funding by NIDA, which supported examination of the precursors and explanatory factors associated with girls'early substance use. The proposed research, through five yearly follow-up assessments of the child, the main caretaker, and teachers, extends this line of inquiry into the developmental period from age 10 to 17, when we expect that girls'substance use, substance- related problems, and comorbid conditions will increase.
The aims of the proposed research are to: (1) describe developmental sequences of substance use by girls during the transition from childhood into adolescence within and across substances;(2) examine developmental sequences of substance use by girls in conjunction with the developmental course of comorbid conditions, especially psychopathology and other behavior problems;and (3) determine proximal and distal risk and protective factors (both generic and female-specific) for different developmental sequences of substance use by girls. These three aims, in conjunction with the data on early substance use and attitudes already collected, will link childhood factors to substance use during adolescence. The Pittsburgh Girl Study is one of the very few studies in the USA that can examine these relationships from childhood through adolescence.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Special Emphasis Panel (ZRG1-RPHB-H (90))
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Weinberg, Naimah Z
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University of Pittsburgh
Schools of Medicine
United States
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Latendresse, Shawn J; Ye, Feifei; Chung, Tammy et al. (2017) Parental Monitoring and Alcohol Use Across Adolescence in Black and White Girls: A Cross-Lagged Panel Mixture Model. Alcohol Clin Exp Res 41:1144-1153
Chung, Tammy; Cornelius, Jack; Clark, Duncan et al. (2017) Greater Prevalence of Proposed ICD-11 Alcohol and Cannabis Dependence Compared to ICD-10, DSM-IV, and DSM-5 in Treated Adolescents. Alcohol Clin Exp Res 41:1584-1592
Goldschmidt, Andrea B; Lavender, Jason M; Hipwell, Alison E et al. (2017) Emotion Regulation and Loss of Control Eating in Community-Based Adolescents. J Abnorm Child Psychol 45:183-191
Sartor, Carolyn E; Bachrach, Rachel L; Stepp, Stephanie D et al. (2017) The relationship between childhood trauma and alcohol use initiation in Black and White adolescent girls: considering socioeconomic status and neighborhood factors. Soc Psychiatry Psychiatr Epidemiol :
Chung, Tammy; Ye, Feifei; Hipwell, Alison E et al. (2017) Alcohol and marijuana use in pathways of risk for sexually transmitted infection in white and black adolescent females. Subst Abus 38:77-81
Foster, Dawn W; Ye, Feifei; Chung, Tammy et al. (2017) Longitudinal Associations Between Marijuana-Related Cognitions and Marijuana Use in African-American and European-American Girls From Early to Late Adolescence. Psychol Addict Behav :
Scott, Lori N; Zalewski, Maureen; Beeney, Joseph E et al. (2017) Pupillary and affective responses to maternal feedback and the development of borderline personality disorder symptoms. Dev Psychopathol 29:1089-1104
Wright, Aidan G C; Zalewski, Maureen; Hallquist, Michael N et al. (2016) Developmental Trajectories of Borderline Personality Disorder Symptoms and Psychosocial Functioning in Adolescence. J Pers Disord 30:351-72
Stepp, Stephanie D; Scott, Lori N; Jones, Neil P et al. (2016) Negative emotional reactivity as a marker of vulnerability in the development of borderline personality disorder symptoms. Dev Psychopathol 28:213-24
Dermody, Sarah S; Marshal, Michael P; Cheong, JeeWon et al. (2016) Adolescent Sexual Minority Girls Are at Elevated Risk for Use of Multiple Substances. Subst Use Misuse 51:574-85

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