This is a resubmission of 2 R01 DA1282806, """"""""Cognitive Neuropsychology of HIV and Drug Abuse,"""""""" a program of theory driven researchdesigned to test the hypothesisthat HIV infection significantly increases vulnerability to neurobehavioral complications amongsubstance dependent-individuals (SDIs).We propose that certain neurocognitive deficits, such as abnormalities of inhibition and reward processing, will be present among both HIV+ and HIV- SDIs comparedwith persons with no history of drug dependence. Additionally, HIV+ SDIs will show deficits in nondeclarative learning and memory,functions dependent on the integrity of neostriatum, a subcortical region typically affectedprominently by HIV;HIV- SDIs are expectedto show some level of impairment in nondeclarative learning but of lesser severity comparedwith HIV+ SDIs. We propose to moveforwardwith the following primary goals: 1)we will compare HIV+ and matched HIV- SDIs on carefully chosen measuresof response inhibition, impulsive choice, and procedural learning;2) we will recruit and test two control groups of HIV+ and HIV- personswith no history of drug dependence in order to address the potential unique and synergistic effects of a positive HIV serostatuswith a history of substance dependence;3) we will examinethe association of these neurocognitive functions with indices of critical daily and social functions. 4) we will develop and pilot test an MRI protocolfor investigating structural brain integrity among HIV+ and HIV- persons with and without a history of substance dependence. Our model has considerable potential utility as a first step towardstudy of HIV-specific effects on brain function in the context of the more non-specific cognitive effects of drug dependence, an area in which research is lacking. The translational and public health relevance of these studies includes the potential for development of more effective clinical neuropsychological measures for assessment of HIV+ and HIV- SDIs;development of indices with relevance to employment, continued risk behavior and adherence with medication;predicting which cognitive deficits observed might be more likely to remit with abstinence from drugs;anddevelopment of a frameworkfor evaluating and perhaps distinguishing response to treatment of substance dependence among HIV+ and HIV-infected SDIs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA012828-10
Application #
7794853
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Lin, Yu
Project Start
1999-08-20
Project End
2012-09-29
Budget Start
2010-04-01
Budget End
2012-09-29
Support Year
10
Fiscal Year
2010
Total Cost
$430,291
Indirect Cost
Name
University of Illinois at Chicago
Department
Psychiatry
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Keutmann, Michael K; Gonzalez, Raul; Maki, Pauline M et al. (2017) Sex differences in HIV effects on visual memory among substance-dependent individuals. J Clin Exp Neuropsychol 39:574-586
Martin, Eileen; Gonzalez, Raul; Vassileva, Jasmin et al. (2016) Sex and HIV serostatus differences in decision making under risk among substance-dependent individuals. J Clin Exp Neuropsychol 38:404-15
Martin, Eileen; Gonzalez, Raul; Vassileva, Jasmin et al. (2015) Delay discounting is greater among drug users seropositive for hepatitis C but not HIV. Neuropsychology 29:926-32
Albert, Steven M; Martin, Eileen M (2014) HIV and the neuropsychology of everyday life. Neurology 82:2046-7
Wilson, Michael J; Martin-Engel, Lindsay; Vassileva, Jasmin et al. (2013) An investigation of the effects of antiretroviral central nervous system penetration effectiveness on procedural learning in HIV+ drug users. J Clin Exp Neuropsychol 35:915-25
Martin, Eileen M; DeHaan, Samantha; Vassileva, Jasmin et al. (2013) Decision making among HIV+ drug using men who have sex with men: a preliminary report from the Chicago Multicenter AIDS Cohort Study. J Clin Exp Neuropsychol 35:573-83
Liu, Richard T; Vassileva, Jasmin; Gonzalez, Raul et al. (2012) A comparison of delay discounting among substance users with and without suicide attempt history. Psychol Addict Behav 26:980-5
Paxton, Jessica L; Vassileva, Jasmin; Gonzalez, Raul et al. (2012) Neurocognitive performance in drug-dependent males and females with posttraumatic stress disorder symptoms. J Clin Exp Neuropsychol 34:521-30
Martin, Eileen; Gonzalez, Raul; Vassileva, Jasmin et al. (2011) HIV+ men and women show different performance patterns on procedural learning tasks. J Clin Exp Neuropsychol 33:112-20
Gonzalez, Raul; Schuster, Randi M; Vassileva, Jasmin et al. (2011) Impact of HIV and a history of marijuana dependence on procedural learning among individuals with a history of substance dependence. J Clin Exp Neuropsychol 33:735-52

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