In the past two grant cycles, we examined schedules of reinforcement in contingency management (CM) treatments, with the goal of identifying the most efficacious and least costly CM approach. We found that voucher and prize CM are equally efficacious in reducing cocaine use when magnitude of reinforcement is equal (Petry et al., 2005a). Although magnitude affects efficacy (Petry et al., 2004), prize CM can engender equal benefits to voucher CM even when prize CM arranges for lower reinforcement magnitude (Petry et al., 2007a). We also found prize CM to be more cost-effective than voucher CM (Olmstead &Petry, 2009). Our next step relates to understanding how aspects of the prize reinforcement approach impact outcomes. We usually arrange for a 50 percent chance of winning a $1, $20 or $100 prize with each draw. A retrospective analysis (Ghitza et al., 2008) suggests probabilities of winning prizes impact abstinence in the short term, and our data indicate that probabilities of winning $20 and $100 prizes are most strongly related to abstinence during and after treatment. In addition, patients desire a greater variety of prize categories, and availability of more prize category options may improve outcomes. This will be the first prospective trial varying probabilities of winning and prize categories available. We will randomize 300 cocaine-dependent methadone patients to 1 of 6 conditions: (a) a control group, (b) a CM condition that arranges a 100 percent probability of winning a prize with each draw and has 3 prize categories, (c) a CM condition that arranges a 31 percent probability of winning and has 3 prize categories, (d) a CM condition that arranges a 100 percent probability of winning and has 7 prize categories, (e) a CM condition that arranges a 31 percent probability of winning and has 7 prize categories, or (f) usual prize CM with a 50 percent probability of winning from 3 prize categories. Magnitudes of reinforcement will be identical across conditions, but lower overall probability conditions arrange for greater chances of winning larger magnitude prizes. We expect that the new CM conditions will reduce cocaine use relative to the control condition, that 31 percent probability conditions will decrease drug use relative to 100 percent conditions, and that 7-prize category conditions will reduce drug use compared to 3-prize category conditions. In addition, the 31 percent/7-category condition is expected to be most efficacious and improve outcomes relative to usual CM. We will also evaluate effects on secondary outcome measures such as HIV risk behaviors and predictors of outcomes. Results will be instrumental for further developing prize CM to improve outcomes of cocaine-dependent methadone patients.

Public Health Relevance

Prize-based contingency management (CM) is efficacious in improving outcomes, but little research to date has focused on the reinforcement parameters in prize CM and how they impact outcomes. These studies will systematically vary probabilities of winning prizes and the number of prize categories available to identify the most efficacious prize CM approach. The study will be conducted with cocaine-using methadone patients, as this group has significant drug use and related problems, and CM may be cost-effective in this population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
2R01DA013444-10A1
Application #
8008697
Study Section
Risk, Prevention and Intervention for Addictions Study Section (RPIA)
Program Officer
Aklin, Will
Project Start
2000-09-01
Project End
2016-04-30
Budget Start
2011-08-01
Budget End
2012-04-30
Support Year
10
Fiscal Year
2011
Total Cost
$505,322
Indirect Cost
Name
University of Connecticut
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030
Alessi, Sheila M; Rash, Carla J (2017) Treatment Satisfaction in a Randomized Clinical Trial of mHealth Smoking Abstinence Reinforcement. J Subst Abuse Treat 72:103-110
Petry, Nancy M; Alessi, Sheila M; Olmstead, Todd A et al. (2017) Contingency management treatment for substance use disorders: How far has it come, and where does it need to go? Psychol Addict Behav 31:897-906
Meredith, Steven E; Rash, Carla J; Petry, Nancy M (2017) Alcohol use disorders are associated with increased HIV risk behaviors in cocaine-dependent methadone patients. J Subst Abuse Treat 83:10-14
Rash, Carla J; Alessi, Sheila M; Petry, Nancy M (2017) Substance Abuse Treatment Patients in Housing Programs Respond to Contingency Management Interventions. J Subst Abuse Treat 72:97-102
Alessi, Sheila M; Barnett, Nancy P; Petry, Nancy M (2017) Experiences with SCRAMx alcohol monitoring technology in 100 alcohol treatment outpatients. Drug Alcohol Depend 178:417-424
Alessi, Sheila M; Rash, Carla J; Petry, Nancy M (2016) A Randomized Trial of Adjunct mHealth Abstinence Reinforcement With Transdermal Nicotine and Counseling for Smoking Cessation. Nicotine Tob Res :
Rash, Carla J; Petry, Nancy M (2016) Gambling Disorder in the DSM-5: Opportunities to Improve Diagnosis and Treatment Especially in Substance Use and Homeless Populations. Curr Addict Rep 3:249-253
Petry, Nancy M; Rash, Carla J; Alessi, Sheila M (2016) A randomized controlled trial of brief interventions for problem gambling in substance abuse treatment patients. J Consult Clin Psychol 84:874-86
Petry, Nancy M; Alessi, Sheila M; Barry, Danielle et al. (2015) Standard magnitude prize reinforcers can be as efficacious as larger magnitude reinforcers in cocaine-dependent methadone patients. J Consult Clin Psychol 83:464-72
Burch, Ashley E; Rash, Carla J; Petry, Nancy M (2015) Sex effects in cocaine-using methadone patients randomized to contingency management interventions. Exp Clin Psychopharmacol 23:284-90

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