This is a second revision of a competitive renewal R01 proposal of the NEURO-HIV Epidemiologic Study in response to NIDA PAS-07-115 (Non-injection Dug Abuse and HIV/AIDS). The primary study aim is to evaluate the ability of Integrated Family and Cognitive-Behavioral Therapy-HIV Prevention Intervention (IFCBT-HIVPI) to prevent HIV among adult non-injection and injection drug users. Over a 12 week intervention interval, the IFCBT-HIVPI model coordinates the delivery of cognitive- behavioral components during 12 group sessions with a couples and family systems component during 4 couples/family sessions to address HIV risk and protective factors across multiple ecological systems. IFCBT-HIVPI main effects on primary (HIV sexual risk behaviors and HIV drug taking risk behaviors) and secondary (HIV, Chlamydia, gonorrhea, and trichomoniasis incidences and legal involvement, academic achievement, and employment) outcome domains will be evaluated. We also seek to elucidate the degree to which the development of attitudinal and behavior change skills targeted by IFCBT-HIVPI (e.g., rational beliefs, problem solving skill, adaptive couples' communication) result in post-intervention reductions of HIV, sexually transmitted infections (STIs), and HIV risk behaviors. The possibility of effect-modification is also considered with a focus on route of drug administration status (i.e., non-injector/injector), neuropsychological (e.g., executive function), and demographic (i.e., African American/white) factors. The proposed study will randomly assign 360 HIV-negative non-injection and injection drug users recruited from the original NEURO-HIV Epidemiologic Study sample to experimental (IFCBT-HIVPI) and comparison (Brief Psychoeducation Curriculum on HIV Prevention; BPEC-HIV) conditions. The composition of the original NEURO-HIV Epidemiologic Study sample provides the basis to stratify the randomized trial sample across gender and two race/ethnicity (i.e., African American and white) groups by route of drug administration status. An assessment battery comprised of a standardized interview on HIV risk behavior, neuropsychological tests, tools to assess attitudes and behavior change skills targeted by IFCBT-HIVPI, drug and STI urine testing, and serologic tests of HIV will be administered before, during, and after the intervention interval across 18-month post-intervention follow-up. Additional preliminary analyses will be conducted on the randomized trial data to: (1) derive session-by-session measures on mechanisms of change targeted by IFCBT-HIVPI via videotape coding methods; (2) characterize mechanisms of change trajectories that may then be evaluated as plausible intervention moderators if present; and (3) estimate intervention cost-effectiveness. The lack of research on science-based prevention interventions for HIV continues to be a serious gap in the literature with recent HIV trends highlighting significant health disparities, particularly among African American non-injection drug users. If successful, the proposed project should help to identify specific attitudinal and behavior change skills targeted by cognitive- behavioral and couples/family systems interventions that foster subsequent reductions in HIV, STIs and HIV risk behaviors among adult drug users at heightened disease risk.
. Recent estimates suggest that a majority of the 40;000 new cases of HIVreported annually in the US are attributable largely to sexual risk behavior associated with non-injectiondrug use. Additionally; African American drug users exhibit substantial HIV health disparities withAfrican American females being 21 times more likely to contract HIV than white females. The proposedproject is designed to address critical gaps in the HIV prevention science field by evaluating the ability ofan intervention coordinating cognitive-behavioral and couples/family systems components to preventHIV among adult drug users at heightened disease risk.
|Dunne, Eugene M; Hearn, Lauren E; Rose, Jonathan J et al. (2014) ADHD as a risk factor for early onset and heightened adult problem severity of illicit substance use: an accelerated gateway model. Addict Behav 39:1755-8|
|Dunne, Eugene M; Dyer, Typhanye Penniman; Khan, Maria R et al. (2014) HIV prevalence and risk behaviors among African American Women Who Trade Sex for Drugs Versus Economic Resources. AIDS Behav 18:1288-92|
|Whitehead, Nicole Ennis; Hearn, Lauren; Trenz, Rebecca C et al. (2014) Age cohort differences in illicit drug use and hepatitis C among African American substance users. J Addict Dis 33:314-21|
|Keen 2nd, Larry; Khan, Maria; Clifford, Lisa et al. (2014) Injection and non-injection drug use and infectious disease in Baltimore City: differences by race. Addict Behav 39:1325-8|
|Whitehead, Nicole Ennis; Hearn, Lauren E; Marsiske, Michael et al. (2014) Awareness of biologically confirmed HCV among a community residing sample of drug users in Baltimore City. J Community Health 39:487-93|
|Harrell, P Truman; Mancha, Brent Edward E; Martins, Silvia S et al. (2014) Cognitive performance profiles by latent classes of drug use. Am J Addict 23:431-9|
|Whitehead, Nicole Ennis; Trenz, Rebecca C; Keen 2nd, Larry et al. (2014) Younger versus older African Americans: patterns and prevalence of recent illicit drug use. J Ethn Subst Abuse 13:126-38|
|Trenz, Rebecca C; Scherer, Michael; Duncan, Alexandra et al. (2013) Latent class analysis of polysubstance use, sexual risk behaviors, and infectious disease among South African drug users. Drug Alcohol Depend 132:441-8|
|Harrell, Paul Truman; Trenz, R C; Scherer, M et al. (2013) A latent class approach to treatment readiness corresponds to a transtheoretical ("Stages of Change") model. J Subst Abuse Treat 45:249-56|
|Scherer, Michael; Trenz, Rebecca; Harrell, Paul et al. (2013) The role of drinking severity on sex risk behavior and HIV exposure among illicit drug users. Am J Addict 22:239-45|
Showing the most recent 10 out of 19 publications